The IL-17 family of cytokines has emerged over the last two decades as a pleiotropic group
of molecules that function in a wide variety of both beneficial and detrimental (pathological) …

The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …

The use of electronic cigarettes (e-cigs) is increasing rapidly, but their effects on lung toxicity
are largely unknown. Smoking is a well-established cause of lung cancer and respiratory …

Once considered as inert, the extracellular matrix recently revealed to be biologically active.
Elastin is one of the most important components of the extracellular matrix. Many vital organs …

Background: Nicotine-containing electronic cigarette (e-cig) use has become widespread.
However, understanding the biological impact of e-cigs compared with smoking on the lung …

To achieve a multidimensional evaluation of chronic obstructive pulmonary disease (COPD)
patients, the spirometry measures are supplemented by assessment of symptoms, risk of …

Rationale: An increased ventilatory response to exertional metabolic demand (high V. e/V.
co2 relationship) is a common finding in patients with coexistent chronic obstructive …

The introduction of microCT has made it possible to show that the terminal bronchioles are
narrowed and destroyed before the onset of emphysematous destruction in COPD. This …

Environmental air irritants including nanosized carbon black (nCB) can drive systemic
inflammation, promoting chronic obstructive pulmonary disease (COPD) and emphysema …

Multicellular organisms synthesize and renew components of their subcellular and
scaffolding proteins, collectively known as the extracellular matrix molecules (ECMs). In the …