This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Bioinspired control of ion transport at the subnanoscale has become a major focus in the
fields of nanofluidics and membrane separation. It is fundamentally important to achieve …

Neural control of the function of visceral organs is essential for homeostasis and health.
Intestinal peristalsis is critical for digestive physiology and host defence, and is often …

Enhanced bursting activity of neurons in the lateral habenula (LHb) is essential in driving
depression-like behaviours, but the cause of this increase has been unknown. Here, using a …

The automobile tire antioxidant N-(1, 3-dimethylbutyl)-N'-phenyl-p-phenylenediamine
(6PPD) and its quinone metabolite 6PPDQ have recently received much attention for their …

Blood flow into the brain is dynamically regulated to satisfy the changing metabolic
requirements of neurons, but how this is accomplished has remained unclear. Here we …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer a promising cell-
based therapy for myocardial infarction. However, the presence of transitory ventricular …