Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

Mitochondria provide numerous essential functions for cells and their dysfunction leads to a
variety of diseases. Thus, obtaining a complete mitochondrial proteome should be a crucial …

One of the most promising areas in the therapeutics for metabolic diseases centers around
activation of the pathways of energy expenditure. Brown adipose tissue is a particularly …

Brown adipose tissue (BAT) dissipates energy as heat to maintain optimal thermogenesis
and to contribute to energy expenditure in rodents and possibly humans. The energetic …

Background Environmental factors can influence obesity by epigenetic mechanisms.
Adipose tissue plays a key role in obesity-related metabolic dysfunction, and gastric bypass …

The cellular uptake of free fatty acids (FFA) is followed by esterification to coenzyme A
(CoA), generating fatty acyl-CoAs that are substrates for oxidation or incorporation into …

The energy expending and glucose sink properties of brown adipose tissue (BAT) make it
an attractive target for new obesity and diabetes treatments. Despite decades of research …

Until recently, intracellular triacylglycerols (TAG) stored in the form of cytoplasmic lipid
droplets have been considered to be only passive “energy conserves”. Nevertheless …

Insulin resistance, a harbinger of the metabolic syndrome, is a state of compromised
hormonal response resulting from the dysregulation of a wide range of insulin-controlled …