Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

Breast cancer is the second leading cause of cancer death in women, affecting 1.7 million
patients every year worldwide. As a result of its heterogeneous nature, the genetic profile …

The multidrug resistance protein MRP1 is an ATP-binding cassette (ABC) transporter that
confers resistance to many anticancer drugs and plays a role in the disposition and efficacy …

The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …

Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …

The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …