Asthma is a heterogenous disease, and its prevalence and severity are different in males
versus females through various ages. As children, boys have an increased prevalence of …

Benzo [a] pyrene (B [a] P) is the main representative of polycyclic aromatic hydrocarbons
(PAHs), and has been repeatedly found in the air, surface water, soil, and sediments. It is …

Epigenetics in Disease Prevention and Mitigation Epigenetics is the regulation of gene
expression through alterations in DNA or associated factors (other than the DNA sequence) …

DNA methylation is the most well studied of the epigenetic regulators in relation to
environmental exposures. To date, numerous studies have detailed the manner by which …

This is an update of the Norwegian Mother and Child Cohort Study (MoBa) cohort profile
which was published in 2006. Pregnant women attending a routine ultrasound examination …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

Excessive exposure to polycyclic aromatic hydrocarbons (PAHs) often results in lung cancer,
a disease with the highest cancer mortality in the United States. After entry into the lung …

Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor
genotype variations among tumors within different patients are known as interpatient …

We propose an extension to quantile normalization that removes unwanted technical
variation using control probes. We adapt our algorithm, functional normalization, to the …