Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

The quest to find milder and more sustainable methods to generate highly reactive, carbon-
centred intermediates has led to a resurgence of interest in radical chemistry. In particular …

The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Mechanochemical transformations have made chemists enter unknown territories, forcing a
different chemistry perspective. While questioning or revisiting familiar concepts belonging …

Introduction: Artificial intelligence (AI) has inspired computer-aided drug discovery. The
widespread adoption of machine learning, in particular deep learning, in multiple scientific …

A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a
global health care emergency in the present time. The virus is referred to as SARS-CoV-2 …

Systematically identifying functional peptides is difficult owing to the vast combinatorial
space of peptide sequences. Here we report a machine-learning pipeline that mines the …

Over the last two decades, fluorine substitution has become one of the essential structural
traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster …