Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting
data exist on whether the mortality of patients with sepsis is influenced by the presence of …

Sepsis develops when an infection surpasses local tissue containment. A series of
dysregulated physiological responses are generated, leading to organ dysfunction and a …

Background Cross-sectional and ecological studies indicate that air pollution may be a risk
factor for type 2 diabetes, but prospective data are lacking. Objective We examined the …

Purpose.: Several genes encoding complement system components and fragments are
associated with age-related macular degeneration (AMD). This study was conducted to …

Background and Aims Mesangial C3 deposition is frequently observed in patients with IgA
nephropathy (IgAN). However, the role of complement in the pathogenesis or progression of …

Activation of the innate immune system plays a major role in nonalcoholic fatty liver disease
(NAFLD). The complement system is an important component of innate immunity that …

The complement system has been implicated in obesity, fatty liver, diabetes and
cardiovascular disease (CVD). Complement factors are produced in adipose tissue and …

This review summarizes available evidence on the role of serum complement component 3
(C3), produced by liver, adipocytes and activated macrophages at inflammation sites, and …

As the common factor linking adipose tissue to the metabolic context of obesity, insulin
resistance and atherosclerosis are associated with a low-grade chronic inflammatory status …

Background Obesity in pregnancy is associated with systemic inflammation, immunological
changes and adverse maternal-fetal outcomes. Information on the association between …