The lipid-anchored RAS (Rat sarcoma) small GTPases (guanosine triphosphate hydrolases)
are highly prevalent in human cancer. Traditional strategies of targeting the enzymatic …

In the past few years, nanomaterial-based drug delivery systems have been applied to
enhance the efficacy of therapeutics and to alleviate negative effects through the controlled …

As data emerges on the pathophysiological underpinnings of severe acute respiratory
syndrome coronavirus (SARS-CoV)-2, it is clear that there are considerable variations in its …

The virulence of SARS-CoV-2 decreases with increasing infectivity, the primary approaches
for antiviral treatments will be preventing or minimizing the complications resulting from virus …

Pulmonary complications from stored blood products are the leading cause of mortality
related to transfusion. Transfusion-related acute lung injury is mediated by antibodies or …

Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in
cell survival and death. Autophagy is regulated at various levels and novel modulators of its …

Beyond key functions in hemostasis and thrombosis, platelets are recognized as key players
of inflammation, an underlying feature of a variety of diseases. In this regard, platelets act as …

Background: Our recent studies suggest that sphingomyelin levels in the plasma membrane
influence TF (tissue factor) procoagulant activity. The current study was performed to …

Introduction To tackle challenges associated with traditional drug carriers, investigators have
explored cells, cellular membrane, and macromolecular components including proteins and …

Microfluidic assays are versatile tests which, using only small amounts of blood, enable high
throughput analyses of platelet function in several minutes. In combination with fluorescence …