Lipid profiles of RAS nanoclusters regulate RAS function
Y Zhou, JF Hancock - Biomolecules, 2021 - mdpi.com
The lipid-anchored RAS (Rat sarcoma) small GTPases (guanosine triphosphate hydrolases)
are highly prevalent in human cancer. Traditional strategies of targeting the enzymatic …
are highly prevalent in human cancer. Traditional strategies of targeting the enzymatic …
Recent advancements in erythrocytes, platelets, and albumin as delivery systems
P Xu, R Wang, X Wang, J Ouyang - OncoTargets and therapy, 2016 - Taylor & Francis
In the past few years, nanomaterial-based drug delivery systems have been applied to
enhance the efficacy of therapeutics and to alleviate negative effects through the controlled …
enhance the efficacy of therapeutics and to alleviate negative effects through the controlled …
COVID-19 pathophysiology: Interactions of gut microbiome, melatonin, vitamin D, stress, kynurenine and the alpha 7 nicotinic receptor: Treatment implications
G Anderson, RJ Reiter - Melatonin research, 2020 - melatonin-research.net
As data emerges on the pathophysiological underpinnings of severe acute respiratory
syndrome coronavirus (SARS-CoV)-2, it is clear that there are considerable variations in its …
syndrome coronavirus (SARS-CoV)-2, it is clear that there are considerable variations in its …
The basis of complications in the context of SARS-CoV-2 infection: pathological activation of ADAM17
S Jiang, H Yang, Z Sun, Y Zhang, Y Li, J Li - Biochemical and Biophysical …, 2023 - Elsevier
The virulence of SARS-CoV-2 decreases with increasing infectivity, the primary approaches
for antiviral treatments will be preventing or minimizing the complications resulting from virus …
for antiviral treatments will be preventing or minimizing the complications resulting from virus …
Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets
MJ McVey, M Kim, A Tabuchi… - … of Physiology-Lung …, 2017 - journals.physiology.org
Pulmonary complications from stored blood products are the leading cause of mortality
related to transfusion. Transfusion-related acute lung injury is mediated by antibodies or …
related to transfusion. Transfusion-related acute lung injury is mediated by antibodies or …
The emerging role of acid sphingomyelinase in autophagy
Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in
cell survival and death. Autophagy is regulated at various levels and novel modulators of its …
cell survival and death. Autophagy is regulated at various levels and novel modulators of its …
Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications
Beyond key functions in hemostasis and thrombosis, platelets are recognized as key players
of inflammation, an underlying feature of a variety of diseases. In this regard, platelets act as …
of inflammation, an underlying feature of a variety of diseases. In this regard, platelets act as …
Alterations to sphingomyelin metabolism affect hemostasis and thrombosis
Background: Our recent studies suggest that sphingomyelin levels in the plasma membrane
influence TF (tissue factor) procoagulant activity. The current study was performed to …
influence TF (tissue factor) procoagulant activity. The current study was performed to …
Research progress in bioinspired drug delivery systems
Q Tong, N Qiu, J Ji, L Ye, G Zhai - Expert Opinion on Drug Delivery, 2020 - Taylor & Francis
Introduction To tackle challenges associated with traditional drug carriers, investigators have
explored cells, cellular membrane, and macromolecular components including proteins and …
explored cells, cellular membrane, and macromolecular components including proteins and …
Whole blood based multiparameter assessment of thrombus formation in standard microfluidic devices to proxy in vivo haemostasis and thrombosis
I Provenzale, SLN Brouns, PEJ van der Meijden… - Micromachines, 2019 - mdpi.com
Microfluidic assays are versatile tests which, using only small amounts of blood, enable high
throughput analyses of platelet function in several minutes. In combination with fluorescence …
throughput analyses of platelet function in several minutes. In combination with fluorescence …