Ancient DNA analysis
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …
first ancient nuclear genomes could only be characterized after high-throughput sequencing …
Macrophage: a cell with many faces and functions in tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
The source of the Black Death in fourteenth-century central Eurasia
The origin of the medieval Black Death pandemic (ad 1346–1353) has been a topic of
continuous investigation because of the pandemic's extensive demographic impact and long …
continuous investigation because of the pandemic's extensive demographic impact and long …
Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most
prevalent in Northern Europe. Although it is known that inherited risk for MS is located within …
prevalent in Northern Europe. Although it is known that inherited risk for MS is located within …
Human ancient DNA analyses reveal the high burden of tuberculosis in Europeans over the last 2,000 years
Tuberculosis (TB), usually caused by Mycobacterium tuberculosis bacteria, is the first cause
of death from an infectious disease at the worldwide scale, yet the mode and tempo of TB …
of death from an infectious disease at the worldwide scale, yet the mode and tempo of TB …
Evolution and emergence of Mycobacterium tuberculosis
M Orgeur, C Sous, J Madacki… - FEMS Microbiology …, 2024 - academic.oup.com
Tuberculosis (TB) remains one of the deadliest infectious diseases in human history,
prevailing even in the 21st century. The causative agents of TB are represented by a group …
prevailing even in the 21st century. The causative agents of TB are represented by a group …
Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations
Previous ancient DNA research has shown that Mycobacterium pinnipedii, which today
causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the …
causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the …
The recovery, interpretation and use of ancient pathogen genomes
The ability to sequence genomes from ancient biological material has provided a rich source
of information for evolutionary biology and engaged considerable public interest. Although …
of information for evolutionary biology and engaged considerable public interest. Although …
Lineage specific histories of Mycobacterium tuberculosis dispersal in Africa and Eurasia
MB O'Neill, A Shockey, A Zarley, W Aylward… - Molecular …, 2019 - Wiley Online Library
Mycobacterium tuberculosis (M. tb) is a globally distributed, obligate pathogen of humans
that can be divided into seven clearly defined lineages. An emerging consensus places the …
that can be divided into seven clearly defined lineages. An emerging consensus places the …
Ancient pathogens provide a window into health and well-being
This perspective draws on the record of ancient pathogen genomes and microbiomes
illuminating patterns of infectious disease over the course of the Holocene in order to …
illuminating patterns of infectious disease over the course of the Holocene in order to …