Upon recognizing cognate antigen, B cells mobilize multiple cellular apparatuses to
propagate an optimal response. Antigen binding is transduced into cytoplasmic signaling …

Phosphoinositides regulate many cellular processes, and cellular levels are controlled by
kinases and phosphatases. SHIP2 (SH2 (Src homology 2)-domain-containing inositol …

Human monocytic and professional antigen-presenting cells have been reported only to
exhibit abortive infections with vaccinia virus (VACV). We found that monocyte-derived …

Phosphoinositide 5-phosphatases are critical enzymes in modulating the concentrations of
PI (3, 4, 5) P 3, PI (4, 5) P 2 and PI (3, 5) P 2. The SH2 domain containing inositol 5 …

Phosphoinositide 5-phosphatases are critical enzymes in modulating the concentrations of
PI (3, 4, 5) P3, PI (4, 5) P2 and PI (3, 5) P2. The SH2 domain containing inositol 5 …

The modern approach to developing attenuated smallpox vaccines usually consists in
targeted inactivation of vaccinia virus (VACV) virulence genes. In this work, we studied how …

Cell migration is an important process that occurs during development and has also been
linked to the motility of cancer cells. Cytoskeleton reorganization takes place in the migration …

The development of an effective HIV-1 vaccine is still a global priority. In recent years,
vaccinia virus (VV) has been widely used as an HIV-1 vaccine vector, but its immune efficacy …

The SH2 containing inositol 5-phosphatase SHIP2 is a member of the mammalian
phosphoinositide polyphosphate 5-phosphatase family. It is a multi-domain protein …

Abstract SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) binds with the Y1356-
phosphorylated hepatocyte growth factor (HGF) receptor, c-MET, through its SH2 domain …