The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a
transmembrane protein that can be activated by various physical and chemical stimuli and is …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

1 Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin. The
present study shows the capsazepine acts as a competitive antagonist of capsaicin. 2 …

Body fluid homeostasis requires the release of arginine-vasopressin (AVP, an antidiuretic
hormone) from the neurohypophysis. This release is controlled by specific and highly …

During dermal injury and the associated trauma a number of compounds are released that
can mediate the inflammatory response. Determining the cellular mechanisms that initiate …

The data reviewed in this article suggest that protons should no longer be considered simply
as an unwanted by-product of anaerobic respiration that results from either an accumulation …

Capsaicin (CAP), a neurotoxin, has been reported to activate a nonselective cation current
in dorsal root ganglion (DRG) neurons. In this paper, we identify and describe the properties …