This study investigates the antinociception caused by intradermal (id) or
intracerebroventricular (icv) injection of the capsaicin receptor antagonist capsazepine …

The dental phenolic medicaments, eugenol and guaiacol, are partly similar in chemical
structure to capsaicin, the pungent constituent of chili peppers, which selectively activates …

[3H] Resiniferatoxin (RTX) binding and calcium uptake by rat dorsal root ganglion (DRG)
neurons show distinct structure-activity relations, suggestive of independent vanilloid …

Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …

In the isolated rat mesenteric bed, the 1 min perfusion with 100 nm anandamide, a
concentration that did not evoke vasorelaxation, elicited an acute release of 165.1±9.2 pmol …

A major problem in clinical trials of tumor necrosis factor-related apoptosis-inducing ligand
(TRAIL) as cancer therapy is the development of resistance to TRAIL. Therefore, agents that …

Cough is currently the most common reason for patients to visit a primary care physician in
the UK, yet it remains an unmet medical need. Current therapies have limited efficacy or …

Capsaicin produces pain by selectively activating polymodal nociceptive neurons. This
involves a membrane depolarization and the opening of a unique, cation-selective, ion …

Intraplantar injection of capsaicin (1.6 μg/paw) into the mouse hindpaw produced an acute
paw-licking/biting response. This study was designed (1) to investigate the antinociceptive …

Inflammation is one of the main causes of pathologic pain. Knowledge of the molecular links
between inflammatory signals and pain-mediating neuronal signals is essential for …