A model employing perfusion of artificial cerebrospinal fluid from the lateral ventricle to the
cisterna magna in the halothane anesthetized rat was used to study β-endorphin release in …

Defunctionalization of capsaicin-sensitive afferent nerves by pretreatment with a neurotoxic
dose of capsaicin aggravates gastric ulcers in rats. In the present study, we investigated the …

Capsaicin antagonists including ruthenium red, capsazepine and iodo-resiniferatoxin (I-
RTX) have recently been shown to inhibit the activation by noxious heat of the capsaicin …

The effect of iodo-resiniferatoxin (I-RTX) on efferent function (tachykinergic contractions of
airway smooth muscle) and afferent function (action potential discharge) of vagal C-fibers …

Capsaicin analogues are typically synthetized by condensation of the amide group of
vanillylamine with a fatty acid derivative. The enzyme of choice to perform this reaction is …

Anandamide has been characterized as both an endocannabinoid and endovanilloid.
Consistent with its actions as an endovanilloid, previous studies have demonstrated that …

TRPV1 has emerged as a promising therapeutic target for pain as well as a broad range of
other conditions such as asthma or urge incontinence. The identification of resiniferatoxin as …

Pain is a cardinal feature of normal physiological protective mechanisms to avoid tissue
damage. In the periphery pain is signalled by fine C and A δ afferent nerve fibres which …

A RECENT report from the Recombinant DNA Advisory Committee lists 393 approved
human gene therapy protocols (www. od. nih. gov/oba/documents. htm). Of these, 33 are for …

Vanilloid VR1 receptors are located in the dorsal horn of the spinal cord. The aim of the
present study was to determine the role of spinal vanilloid receptors (VR1) during …