Natural products from filamentous fungi and production by heterologous expression

F Alberti, GD Foster, AM Bailey - Applied microbiology and biotechnology, 2017 - Springer
Filamentous fungi represent an incredibly rich and rather overlooked reservoir of natural
products, which often show potent bioactivity and find applications in different fields …

Structure, specificity and function of cyclomaltodextrinase, a multispecific enzyme of the α-amylase family

KH Park, TJ Kim, TK Cheong, JW Kim, BH Oh… - … et Biophysica Acta (BBA …, 2000 - Elsevier
Cyclomaltodextrinase (CDase, EC 3.2. 1.54), maltogenic amylase (EC 3.2. 1.133), and
neopullulanase (EC 3.2. 1.135) are reported to be capable of hydrolyzing all or two of the …

Aspergillus: A powerful protein production platform

F Ntana, UH Mortensen, C Sarazin, R Figge - Catalysts, 2020 - mdpi.com
Aspergilli have been widely used in the production of organic acids, enzymes, and
secondary metabolites for almost a century. Today, several GRAS (generally recognized as …

Molecular biology of the Koji molds

K Kitamoto - Advances in applied microbiology, 2002 - books.google.com
Molecular biology of the Koji molds Page 137 Molecular Biology of the Koji Molds KATSUHIKO
KITAMOTO Department of Biotechnology, Graduate School of Agricultural and Life Sciences …

Molecular Cloning and Characterization of a Transcriptional Activator Gene, amyR, Involved in the Amylolytic Gene Expression in Aspergillus oryzae

K Gomi, T Akeno, T Minetoki, K Ozeki… - Bioscience …, 2000 - academic.oup.com
A gene, designated amyR, coding for a transcriptional activator involved in amylolytic gene
expression has been cloned from Aspergillus oryzae by screening for a clone that enabled …

Regulatory mechanisms for amylolytic gene expression in the koji mold Aspergillus oryzae

K Gomi - Bioscience, Biotechnology, and Biochemistry, 2019 - academic.oup.com
The koji mold Aspergillus oryzae has been used in traditional Japanese food and beverage
fermentation for over a thousand years. Amylolytic enzymes are important in sake …

A toolkit for heterologous expression of metabolic pathways in Aspergillus oryzae

KAK Pahirulzaman, K Williams, CM Lazarus - Methods in enzymology, 2012 - Elsevier
Much has been learned about the activities of the key enzymes involved in eukaryotic
natural product synthesis by isolating the relevant genes and expressing them in a suitable …

Construction of a fusion gene comprising the Taka-amylase A promoter and the Escherichia coli β-glucuronidase gene and analysis of its expression in Aspergillus …

S Tada, K Gomi, K Kitamoto, K Takahashi… - Molecular and General …, 1991 - Springer
Northern blot analysis of glucose-grown and starch-grown mycelia of Aspergillus oryzae
R11340 was conducted using the cloned Taka-amylase A (TAA) gene as a probe. The …

Molecular genetic strain improvement for the overproduction of fungal proteins by filamentous fungi

JC Verdoes, PJ Punt, C Van den Hondel - Applied microbiology and …, 1995 - Springer
During the last 5 years, strain improvement by genetic engineering has been established as
a good alternative for traditional methods of strain improvement such as mutagenesis and …

Rapid Reconstitution of Biosynthetic Machinery for Fungal Metabolites in Aspergillus oryzae: Total Biosynthesis of Aflatrem

K Tagami, A Minami, R Fujii, C Liu, M Tanaka… - …, 2014 - Wiley Online Library
Reconstitution of the biosynthetic machinery for fungal secondary metabolites in Aspergillus
oryzae provides an opportunity both for stepwise determination of the biosynthetic pathways …