Celastrol: a spectrum of treatment opportunities in chronic diseases

R Cascão, JE Fonseca, LF Moita - Frontiers in medicine, 2017 - frontiersin.org
The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

SR Chen, Y Dai, J Zhao, L Lin, Y Wang… - Frontiers in …, 2018 - frontiersin.org
Triptolide and celastrol are predominantly active natural products isolated from the
medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar …

Salvia miltiorrhiza polysaccharide and its related metabolite 5-methoxyindole-3-carboxaldehyde ameliorate experimental colitis by regulating Nrf2/Keap1 signaling …

YP Fu, X Peng, CW Zhang, QX Jiang, CY Li… - Carbohydrate …, 2023 - Elsevier
The roots of Salvia miltiorrhiza have been used in Traditional Chinese Medicine for
thousands of years. However, tons of aerial parts of this plant are usually discarded in the …

Celastrol: progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology

W Hou, B Liu, H Xu - European journal of medicinal chemistry, 2020 - Elsevier
Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained
extensive exploration due to its unique structure features and multiple promising biological …

Control of autoimmune inflammation by celastrol, a natural triterpenoid

SH Venkatesha, S Dudics, B Astry… - Fems Pathogens and …, 2016 - academic.oup.com
Celastrol is a bioactive compound derived from traditional Chinese medicinal herbs of the
Celastraceae family. Celastrol is known to possess anti-inflammatory and anti-oxidant …

Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol

Y Lu, Y Liu, J Zhou, D Li, W Gao - Medicinal research reviews, 2021 - Wiley Online Library
Celastrol, a quinone‐methide triterpenoid, was extracted from Tripterygium wilfordii Hook. F.
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …

[HTML][HTML] Molecular modulators of celastrol as the keystones for its diverse pharmacological activities

SW Ng, Y Chan, DK Chellappan… - Biomedicine & …, 2019 - Elsevier
In the recent years, much attention has been focused on identifying bioactive compounds
from medicinal plants that could be employed in therapeutics, which is attributed to their …

Application of amino acids in the structural modification of natural products: A review

Q Xu, H Deng, X Li, ZS Quan - Frontiers in Chemistry, 2021 - frontiersin.org
Natural products and their derivatives are important sources for drug discovery; however,
they usually have poor solubility and low activity and require structural modification. Amino …

The genus Tripterygium: A phytochemistry and pharmacological review

H Lv, L Jiang, M Zhu, Y Li, M Luo, P Jiang, S Tong… - Fitoterapia, 2019 - Elsevier
The genus Tripterygium belongs to the family Celastraceae, and contains three species, ie
Tripterygium wilfordii Hook. F, Tripterygium hypoglaucum (Levl.) Hutch. and Tripterygium …

The ameliorative effect of Lactobacillus plantarum-12 on DSS-induced murine colitis

M Sun, Y Liu, Y Song, Y Gao, F Zhao, Y Luo, F Qian… - Food & function, 2020 - pubs.rsc.org
Some strains of lactobacilli can exert beneficial effects on a host when ingested in an
adequate dose, such as immunoregulation and anti-inflammatory activities. In this study, the …