Celastrol: a spectrum of treatment opportunities in chronic diseases
The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …
therapeutic properties has attracted considerable interest in recent years. Such is the case of …
A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
Triptolide and celastrol are predominantly active natural products isolated from the
medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar …
medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar …
Salvia miltiorrhiza polysaccharide and its related metabolite 5-methoxyindole-3-carboxaldehyde ameliorate experimental colitis by regulating Nrf2/Keap1 signaling …
YP Fu, X Peng, CW Zhang, QX Jiang, CY Li… - Carbohydrate …, 2023 - Elsevier
The roots of Salvia miltiorrhiza have been used in Traditional Chinese Medicine for
thousands of years. However, tons of aerial parts of this plant are usually discarded in the …
thousands of years. However, tons of aerial parts of this plant are usually discarded in the …
Celastrol: progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology
W Hou, B Liu, H Xu - European journal of medicinal chemistry, 2020 - Elsevier
Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained
extensive exploration due to its unique structure features and multiple promising biological …
extensive exploration due to its unique structure features and multiple promising biological …
Control of autoimmune inflammation by celastrol, a natural triterpenoid
SH Venkatesha, S Dudics, B Astry… - Fems Pathogens and …, 2016 - academic.oup.com
Celastrol is a bioactive compound derived from traditional Chinese medicinal herbs of the
Celastraceae family. Celastrol is known to possess anti-inflammatory and anti-oxidant …
Celastraceae family. Celastrol is known to possess anti-inflammatory and anti-oxidant …
Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol
Y Lu, Y Liu, J Zhou, D Li, W Gao - Medicinal research reviews, 2021 - Wiley Online Library
Celastrol, a quinone‐methide triterpenoid, was extracted from Tripterygium wilfordii Hook. F.
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …
[HTML][HTML] Molecular modulators of celastrol as the keystones for its diverse pharmacological activities
In the recent years, much attention has been focused on identifying bioactive compounds
from medicinal plants that could be employed in therapeutics, which is attributed to their …
from medicinal plants that could be employed in therapeutics, which is attributed to their …
Application of amino acids in the structural modification of natural products: A review
Q Xu, H Deng, X Li, ZS Quan - Frontiers in Chemistry, 2021 - frontiersin.org
Natural products and their derivatives are important sources for drug discovery; however,
they usually have poor solubility and low activity and require structural modification. Amino …
they usually have poor solubility and low activity and require structural modification. Amino …
The genus Tripterygium: A phytochemistry and pharmacological review
H Lv, L Jiang, M Zhu, Y Li, M Luo, P Jiang, S Tong… - Fitoterapia, 2019 - Elsevier
The genus Tripterygium belongs to the family Celastraceae, and contains three species, ie
Tripterygium wilfordii Hook. F, Tripterygium hypoglaucum (Levl.) Hutch. and Tripterygium …
Tripterygium wilfordii Hook. F, Tripterygium hypoglaucum (Levl.) Hutch. and Tripterygium …
The ameliorative effect of Lactobacillus plantarum-12 on DSS-induced murine colitis
M Sun, Y Liu, Y Song, Y Gao, F Zhao, Y Luo, F Qian… - Food & function, 2020 - pubs.rsc.org
Some strains of lactobacilli can exert beneficial effects on a host when ingested in an
adequate dose, such as immunoregulation and anti-inflammatory activities. In this study, the …
adequate dose, such as immunoregulation and anti-inflammatory activities. In this study, the …