Molecular Mechanism of Oocyte Activation in Mammals: Past, Present, and Future Directions

H Sugita, S Takarabe, A Kageyama, Y Kawata, J Ito - Biomolecules, 2024 - mdpi.com
During mammalian fertilization, repetitive intracellular Ca2+ increases known as Ca2+
oscillations occur. These oscillations are considered crucial for successful fertilization and …

Long-run real-time PCR analysis of repetitive nuclear elements as a novel tool for DNA damage quantification in single cells: an approach validated on mouse oocytes …

K Kotarska, Ł Gąsior, J Rudnicka, Z Polański - Journal of Applied Genetics, 2024 - Springer
Since DNA damage is of great importance in various biological processes, its rate is
frequently assessed both in research studies and in medical diagnostics. The most precise …

Embryology with precision: effective quality control in the in vitro fertilization laboratory

M Basar, E Unsal, Y Ergun - Current Opinion in Obstetrics and …, 2024 - journals.lww.com
The purpose of this review is to address the critical need for standardization and clarity in the
use of key performance indicators (KPIs) within the realm of in vitro fertilization (IVF) …

[HTML][HTML] Enhancing oocyte in vitro maturation and quality by melatonin/bilirubin cationic nanoparticles: A promising strategy for assisted reproduction techniques

H Xi, L Huang, L Qiu, S Li, Y Yan, Y Ding, Y Zhu… - International Journal of …, 2024 - Elsevier
In assisted reproduction techniques, oocytes encounter elevated levels of reactive oxygen
species (ROS) during in vitro maturation (IVM). Oxidative stress adversely affects oocyte …

Deficiency of MFSD6L, an acrosome membrane protein, causes oligoasthenoteratozoospermia in humans and mice

D Zhou, H Wu, L Wang, X Wang, S Tang, Y Zhou… - Journal of Genetics and …, 2024 - Elsevier
Oligoasthenoteratozoospermia is an important factor affecting male fertility and has been
found to be associated with genetic factors. However, there are still a proportion of …

Pregnancy and neonatal outcomes of ICSI using pentoxifylline to identify viable spermatozoa in patients with frozen-thawed testicular spermatozoa

J Dong, M Yin, L Wu, T Wang, M Li, W Zhang… - Frontiers in …, 2024 - frontiersin.org
Introduction Although the effectiveness of pentoxifylline (PF) as a selective inhibitor of
phosphodiesterase to enhance sperm motility through increasing cyclic nucleotide in cases …

Early rescue oocyte activation at 5 h post-ICSI is a useful strategy for avoiding unexpected fertilization failure and low fertilization in ICSI cycles

L Xue, S Wang, P Wei, H Liu, X Mao, J Qin… - Frontiers in …, 2024 - frontiersin.org
Introduction Attempts to artificially activate unfertilized oocytes at 24 h post intracytoplasmic
sperm injection (ICSI) have generally resulted in poor outcomes. This study aims to explore …

Artificial oocyte activation improves ICSI outcomes following unexplained fertilisation abnormalities

CL Nicholson, M Dean, A Attia, PA Milne… - Reproductive …, 2024 - Elsevier
Abstract Research Question: Is Artificial Oocyte Activation (AOA) effective for patients with
unexplained low or no fertilisation following IVF/ICSI? Design: All IVF/ICSI cases resulting in …

Advanced Sperm Selection Techniques for Assisted Reproduction

F Cariati, MG Orsi, F Bagnulo, D Del Mondo… - Journal of Personalized …, 2024 - mdpi.com
Male infertility accounts for approximately 40% of infertility cases. There are many causes of
male infertility, including environmental factors, age, lifestyle, infections, varicocele, and …

Unveiling the Secrets of Oocyte Fertilisation Failure, Is Calcium the Only Solution?!: A mini-review

N Adel, H Hassan, M Elmahdy… - Journal of Reproductive …, 2024 - journals.ekb.eg
Total fertilization failure (TFF) refers to the complete inability of all oocytes in a human IVF
cycle to undergo fertilization, even after the administration of intracytoplasmic sperm …