miRNAs insights into rheumatoid arthritis: Favorable and detrimental aspects of key performers

AS Doghish, A Ismail, HA El-Mahdy, SY Elkhawaga… - Life Sciences, 2023 - Elsevier
Rheumatoid arthritis (RA) is a severe autoimmune inflammation that mostly affects the joints.
It's a multifactorial disease. Its clinical picture depends on genetic and epigenetic factors …

The non-coding RNA interactome in joint health and disease

SA Ali, MJ Peffers, MJ Ormseth, I Jurisica… - Nature Reviews …, 2021 - nature.com
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …

[HTML][HTML] Role of Th22 cells in the pathogenesis of autoimmune diseases

Q Jiang, G Yang, F Xiao, J Xie, S Wang, L Lu… - Frontiers in …, 2021 - frontiersin.org
Upon antigenic stimulation, naïve CD4+ T cells differentiate into different subsets and
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …

[HTML][HTML] Molecular and cellular heterogeneity in rheumatoid arthritis: mechanisms and clinical implications

J Zhao, S Guo, SJ Schrodi, D He - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis is an autoimmune disease that exhibits significant clinical
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …

Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway

G Ge, J Bai, Q Wang, X Liang, H Tao, H Chen… - Science China Life …, 2022 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease that eventually leads to
disability. Inflammatory cell infiltration, severe joint breaking and systemic bone loss are the …

[HTML][HTML] Application and pharmacological mechanism of methotrexate in rheumatoid arthritis

Z Zhao, Z Hua, X Luo, Y Li, L Yu, M Li, C Lu… - Biomedicine & …, 2022 - Elsevier
Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about
forty years and to date MTX remains the part of global standard of treatment for RA. The …

[HTML][HTML] Association of atopic dermatitis with autoimmune diseases: A bidirectional and multivariable two-sample mendelian randomization study

W Zhou, J Cai, Z Li, Y Lin - Frontiers in Immunology, 2023 - frontiersin.org
Background Observational studies have suggested the association between atopic
dermatitis (AD) and the risks of autoimmune diseases. It is still unclear, however, whether or …

[HTML][HTML] Gut dysbiosis in autoimmune diseases: Association with mortality

SH Chang, Y Choi - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
To better understand the impact of gut dysbiosis on four autoimmune diseases [Sjögren's
syndrome (SS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple …

[HTML][HTML] Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?

D Ait Eldjoudi, A Cordero Barreal… - International Journal of …, 2022 - mdpi.com
White adipose tissue (WAT) is a specialized tissue whose main function is lipid synthesis
and triglyceride storage. It is now considered as an active organ secreting a plethora of …

The IL17 signaling pathway: a potential signaling pathway mediating gill hyperplasia and inflammation under ammonia nitrogen stress was identified by multi-omics …

L Zhong, S Liu, FY Zuo, Y Geng, P Ouyang… - Science of The Total …, 2023 - Elsevier
Ammonia nitrogen is extremely toxic to aquatic animals, and is also the most common
pollutant in the aquatic environment. In order to investigate the effect of high concentration of …