New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …

Synthetic macromolecular antimicrobials are a highly promising class of therapeutics with
immense potential for combating multidrug resistant microbes. In contrast to conventional …

The origins of our nearly ten‐year research program of chemical and biological
investigations into peptides based on homologated proteinogenic amino acids are …

The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

γ-Amino acids have attracted considerable attention as biologically active compounds in the
central nervous system (CNS) of mammals. Over the last few years, significant interest in the …

The peptide Hd-Pro-Pro-Glu-NH2 is a highly effective catalyst for conjugate addition
reactions between aldehydes and nitroethylene. Only 1 mol% of Hd-Pro-Pro-Glu-NH2 and a …

A highly stereoselective synthesis of novel cyclically constrained γ-amino acid residues is
presented. The key step involves organocatalytic Michael addition of an aldehyde to 1 …

Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene catalyzed by
(S)-diphenylprolinol silyl ether provides β-substituted-δ-nitroalcohols in nearly optically pure …

Over the past 20 years, the field of foldamers has rapidly increased. Many β-peptides have
already been described and shown interesting properties. γ-Peptides have more recently …

Non-natural polymers with well-defined three-dimensional folds offer considerable potential
for engineering novel functions that are outside the scope of biological polymers. Here we …