Modern advances in heterocyclic chemistry in drug discovery
AP Taylor, RP Robinson, YM Fobian… - Organic & …, 2016 - pubs.rsc.org
New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …
Emerging trends in macromolecular antimicrobials to fight multi-drug-resistant infections
Synthetic macromolecular antimicrobials are a highly promising class of therapeutics with
immense potential for combating multidrug resistant microbes. In contrast to conventional …
immense potential for combating multidrug resistant microbes. In contrast to conventional …
The World of β‐ and γ‐Peptides Comprised of Homologated Proteinogenic Amino Acids and Other Components
D Seebach, AK Beck, DJ Bierbaum - Chemistry & biodiversity, 2004 - Wiley Online Library
The origins of our nearly ten‐year research program of chemical and biological
investigations into peptides based on homologated proteinogenic amino acids are …
investigations into peptides based on homologated proteinogenic amino acids are …
Structural chemistry of peptides containing backbone expanded amino acid residues: conformational features of β, γ, and hybrid peptides
PG Vasudev, S Chatterjee, N Shamala… - Chemical …, 2011 - ACS Publications
The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …
Stereoselective synthesis of γ-amino acids
M Ordonez, C Cativiela - Tetrahedron: Asymmetry, 2007 - Elsevier
γ-Amino acids have attracted considerable attention as biologically active compounds in the
central nervous system (CNS) of mammals. Over the last few years, significant interest in the …
central nervous system (CNS) of mammals. Over the last few years, significant interest in the …
Peptide Catalyzed Asymmetric Conjugate Addition Reactions of Aldehydes to Nitroethylene—A Convenient Entry into γ2-Amino Acids
M Wiesner, JD Revell, S Tonazzi… - Journal of the American …, 2008 - ACS Publications
The peptide Hd-Pro-Pro-Glu-NH2 is a highly effective catalyst for conjugate addition
reactions between aldehydes and nitroethylene. Only 1 mol% of Hd-Pro-Pro-Glu-NH2 and a …
reactions between aldehydes and nitroethylene. Only 1 mol% of Hd-Pro-Pro-Glu-NH2 and a …
Stereospecific synthesis of conformationally constrained γ-amino acids: New foldamer building blocks that support helical secondary structure
L Guo, Y Chi, AM Almeida, IA Guzei… - Journal of the …, 2009 - ACS Publications
A highly stereoselective synthesis of novel cyclically constrained γ-amino acid residues is
presented. The key step involves organocatalytic Michael addition of an aldehyde to 1 …
presented. The key step involves organocatalytic Michael addition of an aldehyde to 1 …
Enantioselective Organocatalytic Michael Addition of Aldehydes to Nitroethylene: Efficient Access to γ2-Amino Acids
Y Chi, L Guo, NA Kopf, SH Gellman - Journal of the American …, 2008 - ACS Publications
Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene catalyzed by
(S)-diphenylprolinol silyl ether provides β-substituted-δ-nitroalcohols in nearly optically pure …
(S)-diphenylprolinol silyl ether provides β-substituted-δ-nitroalcohols in nearly optically pure …
Foldamers containing γ-amino acid residues or their analogues: structural features and applications
F Bouillere, S Thétiot-Laurent, C Kouklovsky, V Alezra - Amino Acids, 2011 - Springer
Over the past 20 years, the field of foldamers has rapidly increased. Many β-peptides have
already been described and shown interesting properties. γ-Peptides have more recently …
already been described and shown interesting properties. γ-Peptides have more recently …
A threaded loop conformation adopted by a family of peptoid nonamers
K Huang, CW Wu, TJ Sanborn, JA Patch… - Journal of the …, 2006 - ACS Publications
Non-natural polymers with well-defined three-dimensional folds offer considerable potential
for engineering novel functions that are outside the scope of biological polymers. Here we …
for engineering novel functions that are outside the scope of biological polymers. Here we …