[HTML][HTML] A comparative review on heart ion channels, action potentials and electrocardiogram in rodents and human: extrapolation of experimental insights to clinic

S Joukar - Laboratory Animal Research, 2021 - Springer
Electrocardiogram (ECG) is a non-invasive valuable diagnostic tool that is used in clinics for
investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart …

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology …

KE Odening, AM Gomez, D Dobrev, L Fabritz… - EP …, 2021 - academic.oup.com
Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …

[HTML][HTML] Brugada syndrome: from molecular mechanisms and genetics to risk stratification

IP Popa, DN Șerban, MA Mărănducă… - International Journal of …, 2023 - mdpi.com
Brugada syndrome (BrS) is a rare hereditary arrhythmia disorder, with a distinctive ECG
pattern, correlated with an increased risk of ventricular arrhythmias and sudden cardiac …

[HTML][HTML] Update on genetic basis of Brugada syndrome: monogenic, polygenic or oligogenic?

O Campuzano, G Sarquella-Brugada, S Cesar… - International Journal of …, 2020 - mdpi.com
Brugada syndrome is a rare inherited arrhythmogenic disease leading to ventricular
fibrillation and high risk of sudden death. In 1998, this syndrome was linked with a genetic …

[HTML][HTML] Diffuse fibrosis and repolarization disorders explain ventricular arrhythmias in Brugada syndrome: a computational study

N Biasi, P Seghetti, A Tognetti - Scientific Reports, 2022 - nature.com
In this work, we reported a computational study to quantitatively determine the individual
contributions of three candidate arrhythmic factors associated with Brugada Syndrome. In …

Brugada syndrome: different experimental models and the role of human cardiomyocytes from induced pluripotent stem cells

Y Li, S Lang, I Akin, X Zhou… - Journal of the American …, 2022 - Am Heart Assoc
Brugada syndrome (BrS) is an inherited and rare cardiac arrhythmogenic disease
associated with an increased risk of ventricular fibrillation and sudden cardiac death …

[HTML][HTML] Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes

JG Ma, JI Vandenberg, CA Ng - Frontiers in Physiology, 2023 - frontiersin.org
Advances in next-generation sequencing have been exceptionally valuable for identifying
variants in medically actionable genes. However, for most missense variants there is …

[HTML][HTML] iPSC-cardiomyocyte models of Brugada syndrome—achievements, challenges and future perspectives

A Nijak, J Saenen, AJ Labro, D Schepers… - International journal of …, 2021 - mdpi.com
Brugada syndrome (BrS) is an inherited cardiac arrhythmia that predisposes to ventricular
fibrillation and sudden cardiac death. It originates from oligogenic alterations that affect …

[HTML][HTML] Whole-heart computational modelling provides further mechanistic insights into ST-elevation in Brugada syndrome

EM Wülfers, R Moss, H Lehrmann, T Arentz… - IJC Heart & …, 2024 - Elsevier
Abstract Background Brugada syndrome (BrS) is characterized by dynamic ST-elevations in
right precordial leads and increased risk of ventricular fibrillation and sudden cardiac death …

[HTML][HTML] Human induced pluripotent stem cells as a disease model system for heart failure

A Deicher, T Seeger - Current heart failure reports, 2021 - Springer
Abstract Purpose of Review Heart failure is among the most prevalent disease complexes
overall and is associated with high morbidity and mortality. The underlying aetiology is …