The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …

There is evidence that certain infections may induce obesity. Obese persons may also have
more severe infections and have compromised response to therapies. The objective of this …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and
pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this …

The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …

The aim of this study was to determine whether Galleria mellonella larvae can be used (i) as
an in vivo infection model for Pseudomonas aeruginosa and (ii) for evaluating the …

The treatment of infections in critically ill obese and morbidly obese patients is challenging
because of the combined physiological changes that result from obesity and critical illness …

Purpose The management of peritonitis in critically ill patients is becoming increasingly
complex due to their changing characteristics and the growing prevalence of multidrug …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …