The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

In this article we present a comprehensive review of relevant research and reports on the
GABAA receptor in the aged and Alzheimer's disease (AD) brain. In comparison to …

Abstract Changes in the cholinergic, serotonergic, noradrenergic, dopaminergic, GABAergic
and somatostatinergic neurons were investigated to determine their roles in Alzheimer's …

The main objective of the present study was to determine whether cholinergic markers
(choline acetyltransferase activity and nicotinic and muscarinic receptors) are altered in …

The increased expression and/or abnormal processing of the amyloid precursor protein
(APP) is associated with the formation of amyloid plaques and cerebrovascular amyloid …

The following receptors were assessed post-mortem in the hippocampi (anterior region) of
eight patients with Alzheimer's disease and nine age-matched controls, using …

Transcriptome-wide association studies (TWAS) have been widely used to integrate
transcriptomic and genetic data to study complex human diseases. Within a test dataset …

With more than 4 million Alzheimer's victims nationwide, there is intense research to
elucidate the relationship among the hallmarks of the disease, amyloid plaques …

Cholinergic replacement therapies have yielded little or no clinical improvement in
Alzheimer's disease (AD). Since the number of postsynaptic muscarinic receptors remains …

• A high-affinity muscarinic receptor antagonist, 123 IQNB (3-quinuclidinyl-4-io-dobenzilate
labeled with iodine 123), was used with single photon emission computed tomography to …