The effects of carbachol (CCh), a cholinergic agonist, were compared in voltage-clamped
hippocampal pyramidal neurons in vitro, obtained from normal and fimbria-fornix-lesioned …

Muscarinic receptor binding and choline acetyltransferase (EC 2.3. 1.6.) activity were
assayed in three brain regions of 4-, 12-and 24-month-old Fischer-344 rats. Statistically …

Sensitivity of hippocampal field potentials to local (iontophoretic) application of acetylcholine
(ACh) was investigated in chronic ethanol treated (CET) and sucrose-fed (control) rats. CET …

Rationale: The density of the M2 subtype of muscarinic acetylcholine receptors (mAChR)
has been shown to be reduced in the brain of patients with Alzheimer's disease (AD). It is …

Studies of central cholinergic mechanisms, cholinergic drugs, and Aizheimer's disease (AD)
have been reviewed and analyzed. Although the pronounced cholinergic deficit that exists in …

Z-(R)-1-Azabicyclo [2.2. 2] oct-3-yl (R)-α-hydroxy-α-(1-iodo-1-propen-3-yl)-α-phenylacetate
(Z-IQNP) has high affinity to the M 1 and M 2 muscarinic acetylcholine receptor (mAChR) …

The neurobiology of memory continues to attract the attention of researchers in several
disciplines. Memory is being studied at the molecular, cellular, systems, and organismic …

Abstract The effects of Yi Zhi Fang extract (YZF) on learning and memory performances were
investigated in mice using passive avoidance tasks. Oral administration of YZF improved …

4-[76Br] bromodexetimide and its inactive enantiomer 4-[76Br] bromolevetimide were
prepared via electrophilic bromodesilylation using chloramine-T and no-carrier-added …

For the quantitative imaging of muscarinic acetylcholine receptors (mAChR), we developed
novel PET probes,(+) N-11 C-methyl-3-piperidyl benzilate (11 C-(+) 3-MPB), and its N-alkyl …