Pulmonary delivery of nanomedicines is very promising in lung local disease treatments
whereas several physiological barriers limit its application via the interaction with inhaled …

Highlights•The most common ribonucleic acid interference (RNAi) therapeutics and the
extracellular and intracellular barriers to siRNA delivery were discussed.•We investigated …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with different
antigenic variants, has posed a significant threat to public health. It is urgent to develop …

Since most current studies have focused on exploring how phagocyte internalization of drug-
loaded nanovesicles by macrophages would affect the function and therapeutic effects of …

Direct biomimetic modification of nanoparticles (NPs) with endogenous surfactants is helpful
to improve the biocompatibility of NPs and avoid damage to the physiological function of the …

The respiratory system holds crucial importance in the biology of vertebrate animals. Injuries
of the respiratory system caused by viral infections (eg, by COVID‐19, MERS, and SARS) …

The inherent capacity of all organisms to evolve under selective pressure has created
multidrug-resistant microbes and cells that are now threatening decades of progress in …

Purpose The aim of this study was to understand how coating with a pulmonary surfactant,
namely Alveofact, affects the physicochemical parameters as well as in vitro behavior of …

Pulmonary surfactant has been attempted as a supportive therapy to treat COVID-19.
Although it is mechanistically accepted that the fusion peptide in the S2 subunit of the S …

As a promising strategy, gene delivery for cancer treatment accepts encouraging progress
due to its high efficacy, low toxicity, and exclusive selectivity. However, the delivery …