[HTML][HTML] Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation

X Li, D Liu, Z Xiao, Y Zhao, S Han, B Chen, J Dai - Biomaterials, 2019 - Elsevier
Complete transected spinal cord injury (SCI) severely influences the quality of life and
mortality rates of animals and patients. In the past decade, many simple and combinatorial …

The spinal ependymal zone as a source of endogenous repair cells across vertebrates

CG Becker, T Becker, JP Hugnot - Progress in Neurobiology, 2018 - Elsevier
Spinal cord injury results in the loss of neurons and axonal connections. In mammals,
including humans, this loss is permanent, but is repaired in other vertebrates, such as …

A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair

W Liu, B Xu, W Xue, B Yang, Y Fan, B Chen, Z Xiao… - Biomaterials, 2020 - Elsevier
After spinal cord injury (SCI), endogenous neural/progenitor stem cells (NSPCs) were
activated in neural tissue adjacent to the injured segment, but few cells migrated to the injury …

Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenous neural stem cells for acute spinal cord injury repair

X Li, Y Zhao, S Cheng, S Han, M Shu, B Chen, X Chen… - Biomaterials, 2017 - Elsevier
Studies have shown that endogenous neural stem cells (NSCs) activated by spinal cord
injury (SCI) primarily generate astrocytes to form glial scar. The NSCs do not differentiate …

Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems

Local Burden of Disease HIV Collaborators ladwyer … - Bmc Medicine, 2021 - Springer
Background Human immunodeficiency virus (HIV) remains a public health priority in Latin
America. While the burden of HIV is historically concentrated in urban areas and high-risk …

[HTML][HTML] Gsx1 promotes locomotor functional recovery after spinal cord injury

M Patel, Y Li, J Anderson, S Castro-Pedrido, R Skinner… - Molecular therapy, 2021 - cell.com
Promoting residential cells, particularly endogenous neural stem and progenitor cells
(NSPCs), for tissue regeneration represents a potential strategy for the treatment of spinal …

The activation of dormant ependymal cells following spinal cord injury

FJ Rodriguez-Jimenez, P Jendelova… - Stem Cell Research & …, 2023 - Springer
Ependymal cells, a dormant population of ciliated progenitors found within the central canal
of the spinal cord, undergo significant alterations after spinal cord injury (SCI) …

Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery

R Requejo-Aguilar, A Alastrue-Agudo, M Cases-Villar… - Biomaterials, 2017 - Elsevier
Spinal cord injury (SCI) suffers from a lack of effective therapeutic strategies. Animal models
of acute SCI have provided evidence that transplantation of ependymal stem/progenitor cells …

Bridging the gap with functional collagen scaffolds: tuning endogenous neural stem cells for severe spinal cord injury repair

X Li, J Dai - Biomaterials science, 2018 - pubs.rsc.org
Severe spinal cord injury (SCI) induces massive proliferation of spinal cord neural stem cells
(NSCs), which are considered a promising cell source for therapeutic neural repair …

Functionalized collagen scaffold implantation and cAMP administration collectively facilitate spinal cord regeneration

X Li, J Han, Y Zhao, W Ding, J Wei, J Li, S Han… - Acta biomaterialia, 2016 - Elsevier
Previous studies have demonstrated that several mechanisms, including numerous
inhibitory molecules, weak neurotrophic stimulation and deficient intrinsic regenerative …