[HTML][HTML] The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …
changes in both intracellular and extracellular microenvironments that affect the entire body …
[HTML][HTML] Examining the Role of a Functional Deficiency of Iron in Lysosomal Storage Disorders with Translational Relevance to Alzheimer's Disease
SM LeVine - Cells, 2023 - mdpi.com
The recently presented Azalea Hypothesis for Alzheimer's disease asserts that iron
becomes sequestered, leading to a functional iron deficiency that contributes to …
becomes sequestered, leading to a functional iron deficiency that contributes to …
The Azalea Hypothesis of Alzheimer Disease: A Functional Iron Deficiency Promotes Neurodegeneration
SM LeVine - The Neuroscientist, 2023 - journals.sagepub.com
Chlorosis in azaleas is characterized by an interveinal yellowing of leaves that is typically
caused by a deficiency of iron. This condition is usually due to the inability of cells to …
caused by a deficiency of iron. This condition is usually due to the inability of cells to …
[HTML][HTML] The effect of gastric bypass surgery on cognitive function of Alzheimer's disease and the role of GLP1-SGLT1 pathway
Y Mei, Y Li, Y Cheng, L Gao - Experimental neurology, 2023 - Elsevier
Objective Gastric bypass surgery has been shown to improve metabolic profiles via GLP1,
which may also have cognitive benefits for Alzheimer's disease (AD) patients. However, the …
which may also have cognitive benefits for Alzheimer's disease (AD) patients. However, the …
[HTML][HTML] Urine metabolites and viral pneumonia among children: a case-control study in China
C Liu, Z Zhu, L Du, S Li, Q Zhao, X Wang - Translational Pediatrics, 2023 - ncbi.nlm.nih.gov
Background Viral pneumonia in children is common and has grave consequences. The
study aims to better understand the pathophysiological processes involved in the onset and …
study aims to better understand the pathophysiological processes involved in the onset and …
[HTML][HTML] α-酮戊二酸在代谢综合征中的研究进展
雨含李， 瑗王， 泉袁 - Journal of Sichuan University (Medical …, 2024 - ncbi.nlm.nih.gov
Abstract α-酮戊二酸（ alpha-ketoglutarate, α-KG） 是三羧酸循环的内源性中间代谢产物，
参与多种细胞代谢途径， 作为能量供体、 氨基酸前体、 表观遗传调控因子发挥作用。 α-KG …
参与多种细胞代谢途径， 作为能量供体、 氨基酸前体、 表观遗传调控因子发挥作用。 α-KG …
认知障碍与贫血的相关性研究.
陈代敏， 刘欣彤， 吕洋 - Journal of Modern Medicine & …, 2023 - search.ebscohost.com
目的探讨认知障碍与贫血的相关性. 方法选取2012 年1 月至2021 年12 月重庆医科大学第一
附属医院及2021 年某乡镇医院住院老年患者2089 例作为研究对象, 分为认知正常组(1257 例) …
附属医院及2021 年某乡镇医院住院老年患者2089 例作为研究对象, 分为认知正常组(1257 例) …
Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer disease mouse model via enhancing neurotrophic and synaptic signaling
HB Taha, A Birnbaum, I Matthews, K Aceituno, J Leon… - bioRxiv, 2024 - biorxiv.org
INTRODUCTION: Skeletal muscle regulates central nervous system (CNS) function and
health, activating the muscle-to-brain axis through the secretion of skeletal muscle …
health, activating the muscle-to-brain axis through the secretion of skeletal muscle …
[HTML][HTML] Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon
The oxoglutarate dehydrogenase complex (OGDHc) participates in the tricarboxylic acid
cycle and, in a multi-step reaction, decarboxylates α-ketoglutarate, transfers succinyl to CoA …
cycle and, in a multi-step reaction, decarboxylates α-ketoglutarate, transfers succinyl to CoA …
[HTML][HTML] Hypoxia research, where to now?
Investigating how cells and organisms sense and respond to O 2 levels is essential to our
understanding of physiology and pathology. This field has advanced considerably since the …
understanding of physiology and pathology. This field has advanced considerably since the …