▪ Abstract Most prokaryotic signal-transduction systems and a few eukaryotic pathways use
phosphotransfer schemes involving two conserved components, a histidine protein kinase …

Genomic studies have revealed the presence of Ser/Thr kinases and phosphatases in many
bacterial species, although their physiological roles have largely been unclear. Here we …

In bacteria, extracellular signals are generally transduced into cellular responses via a two-
component system. However, genome sequence data have now revealed the presence of …

The central role of serine/threonine and tyrosine protein kinases in signal transduction and
cellular regulation in eukaryotes is well established and widely documented. Considerably …

The eukaryotic protein kinase (ePK) domain mediates the majority of signaling and
coordination of complex events in eukaryotes. By contrast, most bacterial signaling is …

The function of the Mycobacterium tuberculosis eukaryotic‐like protein serine/threonine
kinase PknG was investigated by gene knock‐out and by expression and biochemical …

Inspection of the genomes for the bacteria Bacillus subtilis 168, Borrelia burgdorferi B31,
Escherichia coli K-12, Haemophilus influenzae KW20, Helicobacter pylori 26695 …

Bacterial resistance to aminoglycoside antibiotics is almost exclusively accomplished
through either phosphorylation, adenylylation, or acetylation of the antibacterial agent. The …

The histidyl‐aspartyl phosphorelay, formerly described as the two‐component system, is the
predominant mode of signal transduction in bacteria. Adaptation to environmental changes …

A negative feedback control of kaiC expression by KaiC protein has been proposed to
generate a basic oscillation of the circadian clock in the cyanobacterium Synechococcus sp …