Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …

Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER). Even
with an elaborate network of molecular chaperones and protein folding facilitators …

Cadmium (Cd), a category I human carcinogen, is a well-known widespread environmental
pollutant. Chronic Cd exposure affects different organs and tissues, such as the central …

INTRODUCTION Protein homeostasis in the endoplasmic reticulum (ER) is maintained by a
quality control system. When a newly synthesized ER protein misfolds, it is ultimately …

The Ubiquitin System, Autophagy, and Regulated Protein Degradation | Annual Reviews Menu
Publications AZ Journal Information About Subscribe Give Personal Register/Sign-in 0 Cart …

Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐
mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are …

Reactive oxygen species (ROS) are noxious to cells because their increased level interacts
with the body's defense mechanism. These species also cause mutations and uncontrolled …

The proteostasis network (PN) regulates protein synthesis, folding, transport, and
degradation to maintain proteome integrity and limit the accumulation of protein aggregates …

The unfolded protein response (UPR) is a stress response activated by the accumulation of
unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its …

The AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to a
wide range of cellular functions, including endoplasmic reticulum-associated degradation …