Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by microvascular
vaso-occlusion with erythrocytes containing polymerized sickle (S) hemoglobin, erythrocyte …

Utilizing targeted therapies capable of reducing cancer metastasis, targeting chemoresistant
and self-renewing cancer stem cells, and augmenting the efficacy of systemic …

Migraine stands as one of the most disabling neurological conditions worldwide. It is a
disorder of great challenge to study given its heterogeneous representation, cyclic nature …

Neuronal inflammation is a systematically organized physiological step often triggered to
counteract an invading pathogen or to rid the body of damaged and/or dead cellular debris …

The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the most recent
coronaviruses, which has infected humans, and caused the disease COVID-19. The World …

Kinins are vasoactive peptides that play important roles in cardiovascular homeostasis, pain
and inflammation. After release from their precursor kininogens, kinins or their C-terminal …

Despite improvements in medical and surgical therapies, a significant portion of patients
with critical limb ischemia (CLI) are considered as “no option” for revascularization. In this …

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles
are central to this, yet coordinated movements also exist in sponges that lack these cell …

Background Pulmonary vascular disease, pulmonary endothelial dysfunction, liver fibrosis,
renal disease, and exercise intolerance are common in adults with Fontan physiology …