[HTML][HTML] Novel targeted therapies and immunotherapy for advanced thyroid cancers
Thyroid cancer is a frequently encountered endocrine malignancy. Despite the favorable
prognosis of this disease, 15–20% of differentiated thyroid cancer (DTC) cases and most …
prognosis of this disease, 15–20% of differentiated thyroid cancer (DTC) cases and most …
[HTML][HTML] Molecular alterations in thyroid cancer: from bench to clinical practice
E Tirrò, F Martorana, C Romano, SR Vitale, G Motta… - Genes, 2019 - mdpi.com
Thyroid cancer comprises different clinical and histological entities. Whereas differentiated
(DTCs) malignancies are sensitive to radioiodine therapy, anaplastic (ATCs) and medullary …
(DTCs) malignancies are sensitive to radioiodine therapy, anaplastic (ATCs) and medullary …
Tumor-infiltrating T cells and the PD-1 checkpoint pathway in advanced differentiated and anaplastic thyroid cancer
JJ Bastman, HS Serracino, Y Zhu… - The Journal of …, 2016 - academic.oup.com
Context: Five to 10% of patients with differentiated thyroid cancers (DTC) develop invasive
and/or distant metastatic disease that is marginally improved with standard therapies …
and/or distant metastatic disease that is marginally improved with standard therapies …
[HTML][HTML] Immune cell confrontation in the papillary thyroid carcinoma microenvironment
Z Xie, X Li, Y He, S Wu, S Wang, J Sun, Y He… - Frontiers in …, 2020 - frontiersin.org
Background Papillary thyroid cancer has been associated with chronic inflammation. A
systematic understanding of immune cell infiltration in PTC is essential for subsequent …
systematic understanding of immune cell infiltration in PTC is essential for subsequent …
[HTML][HTML] The immune landscape of thyroid cancer in the context of immune checkpoint inhibition
G Varricchi, S Loffredo, G Marone, L Modestino… - International Journal of …, 2019 - mdpi.com
Immune cells play critical roles in tumor prevention as well as initiation and progression.
However, immune-resistant cancer cells can evade the immune system and proceed to form …
However, immune-resistant cancer cells can evade the immune system and proceed to form …
[HTML][HTML] Regulatory T cells, especially ICOS+ FOXP3+ regulatory T cells, are increased in the hepatocellular carcinoma microenvironment and predict reduced …
JF Tu, YH Ding, XH Ying, FZ Wu, XM Zhou, DK Zhang… - Scientific reports, 2016 - nature.com
Hepatocellular carcinoma (HCC) is a common malignant tumour, especially in Asia. Its
prognosis is poor, and there are limited methods for predicting patient survival. This study …
prognosis is poor, and there are limited methods for predicting patient survival. This study …
MHC Class I Loss Is a Frequent Mechanism of Immune Escape in Papillary Thyroid Cancer That Is Reversed by Interferon and Selumetinib Treatment In Vitro
TE Angell, MG Lechner, JK Jang, JS LoPresti… - Clinical Cancer …, 2014 - AACR
Purpose: To evaluate MHC class I expression on papillary thyroid cancer (PTC) and analyze
changes in MHC expression and associated immune activation with current and …
changes in MHC expression and associated immune activation with current and …
Hashimoto's thyroiditis and papillary thyroid cancer: are they immunologically linked?
M Ehlers, M Schott - Trends in Endocrinology & Metabolism, 2014 - cell.com
Hashimoto's thyroiditis (HT) is the most common autoimmune disease in humans frequently
leading to hypothyroidism. HT is characterized by a cellular immune response with …
leading to hypothyroidism. HT is characterized by a cellular immune response with …
Immunotherapy for advanced thyroid cancers—rationale, current advances and future strategies
JD French - Nature Reviews Endocrinology, 2020 - nature.com
In the past decade, the field of cancer immunotherapy has been revolutionized by immune
checkpoint blockade (ICB) technologies. Success across a broad spectrum of cancers has …
checkpoint blockade (ICB) technologies. Success across a broad spectrum of cancers has …
[HTML][HTML] The role of the tumour microenvironment in immunotherapy
Recent success in immunomodulating strategies in lung cancer and melanoma has
prompted much enthusiasm in their potential to treat other advanced solid malignancies …
prompted much enthusiasm in their potential to treat other advanced solid malignancies …