[HTML][HTML] Novel targeted therapies and immunotherapy for advanced thyroid cancers

GE Naoum, M Morkos, B Kim, W Arafat - Molecular cancer, 2018 - Springer
Thyroid cancer is a frequently encountered endocrine malignancy. Despite the favorable
prognosis of this disease, 15–20% of differentiated thyroid cancer (DTC) cases and most …

[HTML][HTML] Molecular alterations in thyroid cancer: from bench to clinical practice

E Tirrò, F Martorana, C Romano, SR Vitale, G Motta… - Genes, 2019 - mdpi.com
Thyroid cancer comprises different clinical and histological entities. Whereas differentiated
(DTCs) malignancies are sensitive to radioiodine therapy, anaplastic (ATCs) and medullary …

Tumor-infiltrating T cells and the PD-1 checkpoint pathway in advanced differentiated and anaplastic thyroid cancer

JJ Bastman, HS Serracino, Y Zhu… - The Journal of …, 2016 - academic.oup.com
Context: Five to 10% of patients with differentiated thyroid cancers (DTC) develop invasive
and/or distant metastatic disease that is marginally improved with standard therapies …

[HTML][HTML] Immune cell confrontation in the papillary thyroid carcinoma microenvironment

Z Xie, X Li, Y He, S Wu, S Wang, J Sun, Y He… - Frontiers in …, 2020 - frontiersin.org
Background Papillary thyroid cancer has been associated with chronic inflammation. A
systematic understanding of immune cell infiltration in PTC is essential for subsequent …

[HTML][HTML] The immune landscape of thyroid cancer in the context of immune checkpoint inhibition

G Varricchi, S Loffredo, G Marone, L Modestino… - International Journal of …, 2019 - mdpi.com
Immune cells play critical roles in tumor prevention as well as initiation and progression.
However, immune-resistant cancer cells can evade the immune system and proceed to form …

[HTML][HTML] Regulatory T cells, especially ICOS+ FOXP3+ regulatory T cells, are increased in the hepatocellular carcinoma microenvironment and predict reduced …

JF Tu, YH Ding, XH Ying, FZ Wu, XM Zhou, DK Zhang… - Scientific reports, 2016 - nature.com
Hepatocellular carcinoma (HCC) is a common malignant tumour, especially in Asia. Its
prognosis is poor, and there are limited methods for predicting patient survival. This study …

MHC Class I Loss Is a Frequent Mechanism of Immune Escape in Papillary Thyroid Cancer That Is Reversed by Interferon and Selumetinib Treatment In Vitro

TE Angell, MG Lechner, JK Jang, JS LoPresti… - Clinical Cancer …, 2014 - AACR
Purpose: To evaluate MHC class I expression on papillary thyroid cancer (PTC) and analyze
changes in MHC expression and associated immune activation with current and …

Hashimoto's thyroiditis and papillary thyroid cancer: are they immunologically linked?

M Ehlers, M Schott - Trends in Endocrinology & Metabolism, 2014 - cell.com
Hashimoto's thyroiditis (HT) is the most common autoimmune disease in humans frequently
leading to hypothyroidism. HT is characterized by a cellular immune response with …

Immunotherapy for advanced thyroid cancers—rationale, current advances and future strategies

JD French - Nature Reviews Endocrinology, 2020 - nature.com
In the past decade, the field of cancer immunotherapy has been revolutionized by immune
checkpoint blockade (ICB) technologies. Success across a broad spectrum of cancers has …

[HTML][HTML] The role of the tumour microenvironment in immunotherapy

S Gasser, LHK Lim, FSG Cheung - Endocrine-related cancer, 2017 - erc.bioscientifica.com
Recent success in immunomodulating strategies in lung cancer and melanoma has
prompted much enthusiasm in their potential to treat other advanced solid malignancies …