Advances in numerical methods and three-dimensional imaging techniques have enabled
the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic …

An abdominal aortic aneurysm (AAA) is a critical health condition with a risk of rupture,
where the diameter of the aorta enlarges more than 50% of its normal diameter. The …

Murine models have been utilized with increasing frequency mainly due to availability of
genetically engineered models. With advancement in high spatial and temporal resolution …

The objective of our session at the 2008 International Bio-Fluid Symposium and Workshop
was to review the state-of-the-art in image-based modeling of blood flow, and identify future …

Atherosclerosis is inflammation of the vessel wall of the arterial tree. This inflammation
arises at specific areas that experience disturbed blood flow such as bifurcations and the …

This review places modern research developments in vascular mechanobiology in the
context of hemodynamic phenomena in the cardiovascular system and the discrete …

Atherosclerosis develops in the arterial system at sites of low as well as low and oscillating
shear stress. Previously, we demonstrated a shear-related distribution of ciliated endothelial …

Atherosclerosis is a multi-factorial inflammatory disease and is the primary initiator of
coronary artery and cerebrovascular disease. Initially believed to be exclusively lipid-driven …

Background—Extracellular deposition of low-density lipoprotein (LDL) in the arterial wall is
an essential early step in atherosclerosis. This process preferentially occurs at arterial …

Rationale: During the transition from compensated hypertrophy to heart failure, the signaling
between L-type Ca2+ channels in the cell membrane/T-tubules and ryanodine receptors in …