Retrovirus-derived vectors provide efficient means of gene transfer and are potential
excellent tools for therapeutic intervention against congenital or inherited disorders by in …

Objectives: To induce neonatal immune tolerance in immune competent animals by
repeated DNA vaccination. Materials and Methods: We used two groups of neonatal …

MAYO CLINIC Page 1 IN UTERO GENE THERAPY TO CORRECT THE METABOLIC
DEFICIENCY IN MOUSE AND PIG MODELS OF HEREDITARY TYROSINEMIA TYPE 1 A …

Following fetal or neonatal gene transfer in mice and other species immune tolerance of the
transgenic protein is frequently observed; however the underlying mechanisms remain …

Stammzell-, Gen-und Immuntherapie in der Pränatalmedizin 395 entwickelt. Bisher wurden
weltweit insgesamt etwa 40 solcher Transplantationen bei humanen Feten mit …

Gene therapy uses a vector to deliver a gene to its required site where expression of the
protein can produce a therapeutic effect. It may be administered either prenatally or …

Intrauterine gene therapy (IUGT) is designed to treat monogenic diseases in the early stages
of pathogenesis, targeting the disorders that cause severe perinatal morbidity or mortality. I …

There is a worldwide consensus that the incidence of asthma and allergy is exhibiting a
rising trend in western societies. There is also epidemiological evidence that New Zealand …

Gene therapy can be defined as the process by which a normal functional copy of a gene is
transferred into the appropriate cells of an individual with the intent to correct a disease …

Viele genetische Erkrankungen können heute früh in der Schwangerschaft mittels
Chorionzottenbiopsie auf molekularer Ebene diagnostiziert werden. Einige davon können …