The human genome is capable of producing hundreds of thousands of different proteins and
non‐coding RNAs from< 20 000 genes, in a co‐ordinated and regulated fashion. This is …

Cardiac diseases are the leading cause of mortality and morbidity worldwide. Mounting
evidence suggests that transglutaminases (TGs), tissue TG (TG2) in particular, are involved …

Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and
remodeling, which showed high level of phenotypic plasticity. Abnormalities in VSMC …

Arrhythmogenic cardiomyopathy (ACM) is characterized by life-threatening ventricular
arrhythmias and sudden cardiac death and affects hundreds of thousands of patients …

Differentiation of smooth muscle cells (SMCs) depends on serum response factor (SRF) and
its co-activator myocardin (MYOCD). The role of MYOCD for the SMC program of gene …

RNA-binding proteins (RBPs) are involved in the regulation of RNA splicing, stability, and
localization. How RBPs control the development of atherosclerosis, is not fully understood …

Background Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a
hallmark of cancer that profoundly influences the development and progression of prostate …

Fermented beverages, such as wine and beer, are rich in polyphenols that have been
shown to have protective effects against oxidative stress. Oxidative stress plays a central …

The complexity of the cellular proteome facilitates the control of a wide range of cellular
processes. Non-coding RNAs, including microRNAs and long non-coding RNAs, greatly …

Pathological reprogramming of cardiomyocyte and fibroblast proteome landscapes drive the
initiation and progression of cardiac fibrosis. Although the secretome of dysfunctional …