Exploiting RIG-I-like receptor pathway for cancer immunotherapy

Y Jiang, H Zhang, J Wang, J Chen, Z Guo, Y Liu… - Journal of Hematology & …, 2023 - Springer
RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …

The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis

A Nabavi-Rad, A Yadegar, A Sadeghi, HA Aghdaei… - Trends in …, 2023 - cell.com
Chronic infection with Helicobacter pylori is the primary risk factor for the development of
gastric cancer. Hindering our ability to comprehend the precise role of autophagy during H …

Innate immune activation and modulatory factors of Helicobacter pylori towards phagocytic and nonphagocytic cells

L Faass, M Hauke, SC Stein, C Josenhans - Current Opinion in Immunology, 2023 - Elsevier
Highlights•H. pylori is a master influencer of the cell-autonomous immune response.•The H.
pylori Cag type 4 secretion system injects proteins and metabolites.•Bacterial heptose …

Masking of typical TLR4 and TLR5 ligands modulates inflammation and resolution by Helicobacter pylori

SK Pachathundikandi, N Tegtmeyer, S Backert - Trends in Microbiology, 2023 - cell.com
Helicobacter pylori is a paradigm of chronic bacterial infection and is associated with peptic
ulceration and malignancies. H. pylori uses specific masking mechanisms to avoid …

Strategies of Helicobacter pylori in evading host innate and adaptive immunity: insights and prospects for therapeutic targeting

J Fan, J Zhu, H Xu - Frontiers in Cellular and Infection Microbiology, 2024 - frontiersin.org
Helicobacter pylori (H. pylori) is the predominant pathogen causing chronic gastric mucosal
infections globally. During the period from 2011 to 2022, the global prevalence of H. pylori …

The cytosolic DNA sensor AIM2 promotes Helicobacter‐induced gastric pathology via the inflammasome

RE Dawson, V Deswaerte, AC West… - … and Cell Biology, 2023 - Wiley Online Library
Helicobacter pylori (H. pylori) infection can trigger chronic gastric inflammation perpetuated
by overactivation of the innate immune system, leading to a cascade of precancerous …

Therapeutic approach targeting gut microbiome in gastrointestinal infectious diseases

Z Han, Y Min, K Pang, D Wu - International Journal of Molecular Sciences, 2023 - mdpi.com
While emerging evidence highlights the significance of gut microbiome in gastrointestinal
infectious diseases, treatments like Fecal Microbiota Transplantation (FMT) and probiotics …

Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by Helicobacter pylori infection

S Luo, J Ru, MK Mirzaei, J Xue, X Peng, A Ralser… - Gut …, 2023 - Taylor & Francis
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. While
a close correlation between chronic Helicobacter pylori infection and CRC has been …

[HTML][HTML] Helicobacter pylori-associated chronic atrophic gastritis and progression of gastric carcinogenesis

NR Lim, WC Chung - The Korean Journal of Gastroenterology, 2023 - kjg.or.kr
Chronic inflammation due to a Helicobacter pylori (H. pylori) infection is a representative
cause of gastric cancer that can promote gastric carcinogenesis by abnormally activating …

DNA transport through the dynamic type IV secretion system

ME Ryan, PP Damke, CL Shaffer - Infection and Immunity, 2023 - Am Soc Microbiol
The versatile type IV secretion system (T4SS) nanomachine plays a pivotal role in bacterial
pathogenesis and the propagation of antibiotic resistance determinants throughout microbial …