[HTML][HTML] Opportunities and challenges in phenotypic drug discovery: an industry perspective
Phenotypic drug discovery (PDD) approaches do not rely on knowledge of the identity of a
specific drug target or a hypothesis about its role in disease, in contrast to the target-based …
specific drug target or a hypothesis about its role in disease, in contrast to the target-based …
Biomaterials‐based approaches to tumor spheroid and organoid modeling
Evolving understanding of structural and biological complexity of tumors has stimulated
development of physiologically relevant tumor models for cancer research and drug …
development of physiologically relevant tumor models for cancer research and drug …
[HTML][HTML] Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures
Understanding how forces orchestrate tissue formation requires technologies to map
internal tissue stress at cellular length scales. Here, we develop ultrasoft mechanosensors …
internal tissue stress at cellular length scales. Here, we develop ultrasoft mechanosensors …
[HTML][HTML] Mapping cellular-scale internal mechanics in 3D tissues with thermally responsive hydrogel probes
Local tissue mechanics play a critical role in cell function, but measuring these properties at
cellular length scales in living 3D tissues can present considerable challenges. Here we …
cellular length scales in living 3D tissues can present considerable challenges. Here we …
Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis
Cancer is one of the leading causes of death globally according to the World Health
Organization. Although improved treatments and early diagnoses have reduced cancer …
Organization. Although improved treatments and early diagnoses have reduced cancer …
Microfluidic formation of coculture tumor spheroids with stromal cells as a novel 3D tumor model for drug testing
Three-dimensional (3D) tumor spheroids offer unprecedented capability for drug screening
because of their unique features such as spatial 3D structure, relevant physiological …
because of their unique features such as spatial 3D structure, relevant physiological …
Liquid-based three-dimensional tumor models for cancer research and drug discovery
SL Ham, R Joshi, PS Thakuri… - … biology and medicine, 2016 - journals.sagepub.com
Tumors are three-dimensional tissues where close contacts between cancer cells,
intercellular interactions between cancer and stromal cells, adhesion of cancer cells to the …
intercellular interactions between cancer and stromal cells, adhesion of cancer cells to the …
Quantitative size-based analysis of tumor spheroids and responses to therapeutics
PS Thakuri, M Gupta, M Plaster… - ASSAY and Drug …, 2019 - liebertpub.com
Drug resistance remains a major clinical problem despite advances in targeted therapies. In
recent years, methods to culture cancer cells in three-dimensional (3D) environments to …
recent years, methods to culture cancer cells in three-dimensional (3D) environments to …
Engineering of hybrid spheroids of mesenchymal stem cells and drug depots for immunomodulating effect in islet xenotransplantation
Immunomodulation is an essential consideration for cell replacement procedures.
Unfortunately, lifelong exposure to nonspecific systemic immunosuppression results in …
Unfortunately, lifelong exposure to nonspecific systemic immunosuppression results in …
High‐precision 3D bio‐dot printing to improve paracrine interaction between multiple types of cell spheroids
Cell–cell interaction accounts for one of the most influential factors affecting the viability and
functionality of cell‐based tissue models. In this respect, various methods capable of …
functionality of cell‐based tissue models. In this respect, various methods capable of …