Processing of collagen based biomaterials and the resulting materials properties
M Meyer - Biomedical engineering online, 2019 - Springer
Collagen, the most abundant extracellular matrix protein in animal kingdom belongs to a
family of fibrous proteins, which transfer load in tissues and which provide a highly …
family of fibrous proteins, which transfer load in tissues and which provide a highly …
[HTML][HTML] Drug permeability profiling using cell-free permeation tools: Overview and applications
Cell-free permeation systems are gaining interest in drug discovery and development as
tools to obtain a reliable prediction of passive intestinal absorption without the …
tools to obtain a reliable prediction of passive intestinal absorption without the …
Prediction of drug absorption using multivariate statistics
WJ Egan, KM Merz, JJ Baldwin - Journal of medicinal chemistry, 2000 - ACS Publications
Literature data on compounds both well-and poorly-absorbed in humans were used to build
a statistical pattern recognition model of passive intestinal absorption. Robust outlier …
a statistical pattern recognition model of passive intestinal absorption. Robust outlier …
[图书][B] Absorption and drug development: solubility, permeability, and charge state
A Avdeef - 2012 - books.google.com
Explains how to perform and analyze the results of the latest physicochemical methods With
this book as their guide, readers have access to all the current information needed to …
this book as their guide, readers have access to all the current information needed to …
Lipophilicity and its relationship with passive drug permeation
X Liu, B Testa, A Fahr - Pharmaceutical research, 2011 - Springer
In this review, we first summarize the structure and properties of biological membranes and
the routes of passive drug transfer through physiological barriers. Lipophilicity is then …
the routes of passive drug transfer through physiological barriers. Lipophilicity is then …
Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors
H van de Waterbeemd, G Camenisch… - Journal of drug …, 1998 - Taylor & Francis
The influence of physicochemical properties, including lipophilicity, H-bonding capacity and
molecular size and shape descriptors on brain uptake has been investigated using a …
molecular size and shape descriptors on brain uptake has been investigated using a …
Determination of lipophilicity and its use as a predictor of blood–brain barrier penetration of molecular imaging agents
RN Waterhouse - Molecular Imaging & Biology, 2003 - Elsevier
Compound lipophilicity is a fundamental physicochemical property that plays a pivotal role
in the absorption, distribution, metabolism, and elimination (ADME) of therapeutic drugs …
in the absorption, distribution, metabolism, and elimination (ADME) of therapeutic drugs …
Property-based design: optimization of drug absorption and pharmacokinetics
H Van De Waterbeemd, DA Smith… - Journal of medicinal …, 2001 - ACS Publications
Drugs may be administered via different routes, the oral route generally being the preferred
for reasons of ease and compliance by the patient. Absorption via these routes will take …
for reasons of ease and compliance by the patient. Absorption via these routes will take …
Physicochemical profiling (solubility, permeability and charge state)
A Avdeef - Current topics in medicinal chemistry, 2001 - ingentaconnect.com
About 30per4cent of drug candidate molecules are rejected due to pharmacokinetic-related
failures. When poor pharmaceutical properties are discovered in development, the costs of …
failures. When poor pharmaceutical properties are discovered in development, the costs of …
Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
It is generally thought that many drug molecules are transported across biological
membranes via passive diffusion at a rate related to their lipophilicity. However, the types of …
membranes via passive diffusion at a rate related to their lipophilicity. However, the types of …