Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
Biomarkers of aging for the identification and evaluation of longevity interventions
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging
DB Rosoff, LA Mavromatis, AS Bell, J Wagner, J Jung… - Nature aging, 2023 - nature.com
The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …
Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target
CE Trussoni, SP O'Hara, NF LaRusso - Seminars in immunopathology, 2022 - Springer
The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial
cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and …
cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and …
Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise
Aging is typified by a gradual loss of physiological fitness and accumulation of cellular
damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging …
damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging …
Why Gilgamesh failed: the mechanistic basis of the limits to human lifespan
B Milholland, J Vijg - Nature Aging, 2022 - nature.com
The purpose of this Perspective is to clarify for an interdisciplinary audience the fundamental
concepts of human longevity and provide evidence for a limit to human lifespan. This …
concepts of human longevity and provide evidence for a limit to human lifespan. This …
[HTML][HTML] Towards AI-driven longevity research: an overview
While in the past technology has mostly been utilized to store information about the
structural configuration of proteins and molecules for research and medical purposes …
structural configuration of proteins and molecules for research and medical purposes …
Measuring healthy ageing: current and future tools
Human ageing is a complex, multifactorial process characterised by physiological damage,
increased risk of age-related diseases and inevitable functional deterioration. As the …
increased risk of age-related diseases and inevitable functional deterioration. As the …
[HTML][HTML] DNA double-strand breaks as pathogenic lesions in neurological disorders
VE Provasek, J Mitra, VH Malojirao… - International Journal of …, 2022 - mdpi.com
The damage and repair of DNA is a continuous process required to maintain genomic
integrity. DNA double-strand breaks (DSBs) are the most lethal type of DNA damage and …
integrity. DNA double-strand breaks (DSBs) are the most lethal type of DNA damage and …
Deep learning-based age estimation from chest CT scans
Purpose Medical imaging can be used to estimate a patient's biological age, which may
provide complementary information to clinicians compared to chronological age. In this …
provide complementary information to clinicians compared to chronological age. In this …