To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …

Pathogenic species of Legionella can infect human alveolar macrophages through
Legionella-containing aerosols to cause a disease called Legionellosis, which has two …

Extensive use of substances derived from natural sources has been documented in the
treatment of colorectal cancer (CRC). Lysionotin (Lys) is a flavonoid present in the flowers …

ADP-ribosylation is a reversible post-translational modification involved in various cellular
activities. Removal of ADP-ribosylation requires (ADP-ribosyl) hydrolases, with …

Legionella pneumophila strains harboring wild-type rpsL such as Lp02 rpsL WT cannot
replicate in mouse bone marrow-derived macrophages (BMDMs) due to induction of …

Q fever is a zoonotic disease caused by Coxiella burnetii, an obligatory intracellular
bacterial pathogen. Like other intracellular pathogens, C. burnetii is able to survive and …

Adenosine diphosphate (ADP) ribosylation is a reversible posttranslational modification
involved in the regulation of numerous cellular processes. Prototype ADP …

ADP-ribosylation (ADPr) is a dynamically reversible post-translational modification (PTM)
driven primarily by ADP-ribosyltransferases (ADPRTs or ARTs), which have ADP-ribosyl …

Rickettsia is a genus of nonmotile, Gram-negative, non-spore-forming, highly pleomorphic
bacteria that cause severe epidemic rickettsioses. The spotted fever group and typhi group …

As a major virulence factor of Listeria monocytogenes (L. monocytogenes), listeriolysin O
(LLO) can assist in the immune escape of L. monocytogenes, which is critical for the …