Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

Current knowledge suggests that intimal smooth muscle cells (SMCs) in native
atherosclerotic plaque derive mainly from the medial arterial layer. During this process …

In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …

Compared to bare-metal stents (BMSs), drug-eluting stents (DESs) have been regarded as a
revolutionary change in coronary artery diseases (CADs). Releasing pharmaceutical agents …

Forces acting on cells govern many important regulatory events during development, normal
physiology, and disease processes. Integrin-mediated adhesions, which transmit forces …

The formation of atherosclerotic plaques in the large and medium sized arteries is classically
driven by systemic factors, such as elevated cholesterol and blood pressure. However, work …

Background—MicroRNA are essential posttranscriptional modulators of gene expression
implicated in various chronic diseases. Because microRNA-145 is highly expressed in …

Monocyte chemotactic protein-1 (MCP-1)(also referred to as chemokine (CC motif) ligand 2
(CCL2) is expressed by mainly inflammatory cells and endothelial cells. The expression …

Objective—Transsignaling of interleukin (IL)-6 is a central pathway in the pathogenesis of
disorders associated with chronic inflammation, such as Crohn disease, rheumatoid arthritis …