The p53 tumor suppressor protein, that has a fundamental role in growth control and
neoplasia, has been one of the most extensively studied proteins in recent years. The first …

Despite considerable improvements in the tolerance and efficacy of novel chemotherapeutic
agents, the mortality of hematological malignancies is still high due to therapy relapse …

Constitutively activating FLT3 receptor mutations have been found in 35% of patients with
acute myeloblastic leukemia (AML). Here we report the identification of a small molecule …

Vitamin D 3 upregulated protein 1 (VDUP1) is a 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D
3) upregulated protein, and it is induced by various stresses. In human tumor tissues …

Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

Human monocytic THP-1 cells can be induced to differentiate to macrophages when treated
with phorbol 12-myristate 13-acetate (PMA). It is understood that before initiating cell …

Lipoblastomas are rare soft tissue tumors that occur primarily in young children. They
typically contain variably differentiated adipocytes, primitive mesenchymal cells, myxoid …

Abstract Mutant Fms-Like Tyrosine kinase-3 (FLT3), which is expressed in the leukemic cells
of a subpopulation of acute myeloid leukemia (AML) patients, represents an attractive target …

In recent decades we have been given insight into the process that transforms a normal cell
into a malignant cancer cell. It has been recognised that malignant transformation occurs …

Vitexin, a lignan compound, has been shown to exert apoptotic actions on human breast
cancer cell lines and to have anti-inflammatory activities. Nevertheless, there is currently no …