Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease.
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …

Investigators have long suspected that pathogenic microbes might contribute to the onset
and progression of Alzheimer's disease (AD) although definitive evidence has not been …

Crohn's disease (CD), a form of inflammatory bowel disease, has a higher prevalence in
Ashkenazi Jewish than in non-Jewish European populations. To define the role of …

Background Dissecting the regulatory relationships between genes is a critical step towards
building accurate predictive models of biological systems. A powerful approach towards this …

Epigenetic mechanisms represent potential molecular routes which could bridge the gap
between genetic background and environmental risk factors contributing to the …

High-altitude adaptation of Tibetans represents a remarkable case of natural selection
during recent human evolution. Previous genome-wide scans found many non-coding …

Omics approaches are high-throughput unbiased technologies that provide snapshots of
various aspects of biological systems and include: 1) genomics, the measure of DNA …

Elevated plasma cholesterol and type 2 diabetes (T2D) are associated with coronary artery
disease (CAD). Individuals treated with cholesterol-lowering statins have increased T2D …

Liquid biopsy has emerged in the last ten years as an appealing noninvasive strategy to
support early cancer diagnosis and follow-up interventions. However, conventional liquid …