Evolving definitions of frailty, and improved understanding of molecular and physiological
declines in multiple systems that may increase vulnerability in frail, older adults has …

■ ABSTRACT Frailty is a state of vulnerability that carries an increased risk of poor
outcomes in older adults. Common signs and symptoms are fatigue, weight loss, muscle …

Background and aims: The geriatric syndrome of frailty has been conceptualized as a loss of
physiologic reserve associated with endocrine dysregulation and immune dysfunction. Our …

Frailty in older adults is increasingly a recognized syndrome of decline, sometimes subtle, in
function and health that may be amenable to available approaches to care. Frailty manifests …

Frailty is a state of late life decline and vulnerability, typified by physical weakness and
decreased physiologic reserve. The epidemiology and pathophysiology of frailty share …

Frailty and its management represent an emerging area of clinical care in older adults.
Geriatricians have long recognized a syndrome of multiple comorbid conditions, immobility …

Objectives Dementia draws on a variety of public and private resources. There is increasing
pressure to define the cost components in this area to improve resource allocation and …

Chronological age alone does not determine the vulnerability or frailty of an older adult.
Frailty can, however, profoundly affect the quality of an older adult's life. Frail adults could …

What challenges currently prevent an evidence-based care for older adults with cancer?
First, there is a dearth of sufficient high-quality evidence on which to base management …

Objective Self-perceived emotional vitality, intact mood, physical activity, and social
engagement are recognized as important indicators for lowered rates of morbidity and …