Diagnosis and molecular classification of lung cancer
J Rodriguez-Canales, E Parra-Cuentas… - Lung Cancer: Treatment …, 2016 - Springer
Lung cancer is a complex disease composed of diverse histological and molecular types
with clinical relevance. The advent of large-scale molecular profiling has been helpful to …
with clinical relevance. The advent of large-scale molecular profiling has been helpful to …
Clinical implications of genomic discoveries in lung cancer
C Swanton, R Govindan - New England Journal of Medicine, 2016 - Mass Medical Soc
Clinical Implications of Genomic Discoveries in Lung Cancer | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …
Skip to main content The New England Journal of Medicine homepage Advanced Search …
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …
FDA approval summary: nivolumab for the treatment of metastatic non-small cell lung cancer with progression on or after platinum-based chemotherapy
D Kazandjian, DL Suzman, G Blumenthal… - The …, 2016 - academic.oup.com
Abstract On October 9, 2015, the US Food and Drug Administration expanded the nivolumab
metastatic non-small cell lung cancer (NSCLC) indication to include patients with …
metastatic non-small cell lung cancer (NSCLC) indication to include patients with …
[HTML][HTML] Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer
K Azuma, K Ota, A Kawahara, S Hattori, E Iwama… - Annals of oncology, 2014 - Elsevier
Background Recent clinical trials have shown that immune-checkpoint blockade yields a
clinical response in a subset of individuals with advanced nonsmall-cell lung cancer …
clinical response in a subset of individuals with advanced nonsmall-cell lung cancer …
FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the …
CC Sun, W Zhu, SJ Li, W Hu, J Zhang, Y Zhuo… - Genome medicine, 2020 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) are extensively intricate in the
tumorigenesis and metastasis of various cancer types. Nevertheless, the detailed molecular …
tumorigenesis and metastasis of various cancer types. Nevertheless, the detailed molecular …
Induction of PD-L1 expression by the EML4–ALK oncoprotein and downstream signaling pathways in non–small cell lung cancer
K Ota, K Azuma, A Kawahara, S Hattori, E Iwama… - Clinical cancer …, 2015 - AACR
Purpose: Therapies targeted to the immune checkpoint mediated by PD-1 and PD-L1 show
antitumor activity in a subset of patients with non–small cell lung cancer (NSCLC). We have …
antitumor activity in a subset of patients with non–small cell lung cancer (NSCLC). We have …
Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised …
MC Garassino, O Martelli, M Broggini, G Farina… - The lancet …, 2013 - thelancet.com
Background Erlotinib is registered for treatment of all patients with advanced non-small-cell
lung cancer (NSCLC). However, its efficacy for treatment of patients whose tumours are …
lung cancer (NSCLC). However, its efficacy for treatment of patients whose tumours are …
Refining the treatment of NSCLC according to histological and molecular subtypes
In the past decade, the characterization of non-small-cell lung cancer (NSCLC) into
subtypes based on genotype and histology has resulted in dramatic improvements in …
subtypes based on genotype and histology has resulted in dramatic improvements in …
[HTML][HTML] Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Fusions of the RET and ROS1 protein tyrosine kinase oncogenes with several partner genes
were recently identified as new targetable genetic aberrations in cases of non-small cell …
were recently identified as new targetable genetic aberrations in cases of non-small cell …