Meta-hallmarks of aging and cancer
Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
The role of ROS in tumour development and progression
EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial
Fecal microbiota transplantation (FMT) represents a potential strategy to overcome
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …
Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
JL Galeano Niño, H Wu, KD LaCourse… - Nature, 2022 - nature.com
The tumour-associated microbiota is an intrinsic component of the tumour microenvironment
across human cancer types,. Intratumoral host–microbiota studies have so far largely relied …
across human cancer types,. Intratumoral host–microbiota studies have so far largely relied …
Targeting the gut and tumor microbiota in cancer
EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …
A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors
AB Dohlman, J Klug, M Mesko, IH Gao, SM Lipkin… - Cell, 2022 - cell.com
Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …
human microbiome, yet little is known about their role in human cancers. Pan-cancer …
Engineered cellular immunotherapies in cancer and beyond
AV Finck, T Blanchard, CP Roselle, G Golinelli… - Nature medicine, 2022 - nature.com
This year marks the tenth anniversary of cell therapy with chimeric antigen receptor (CAR)-
modified T cells for refractory leukemia. The widespread commercial approval of genetically …
modified T cells for refractory leukemia. The widespread commercial approval of genetically …
[HTML][HTML] Microbiome and cancer
N Cullin, CA Antunes, R Straussman… - Cancer Cell, 2021 - cell.com
The human microbiome constitutes a complex multikingdom community that symbiotically
interacts with the host across multiple body sites. Host-microbiome interactions impact …
interacts with the host across multiple body sites. Host-microbiome interactions impact …
[HTML][HTML] Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
The tumor microenvironment (TME) influences cancer progression and therapy response.
Therefore, understanding what regulates the TME immune compartment is vital. Here we …
Therefore, understanding what regulates the TME immune compartment is vital. Here we …
The coming decade in precision oncology: six riddles
High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …
cancer specialists into the precision oncology era. The singular lesson of precision oncology …