The neural bases of tinnitus: lessons from deafness and cochlear implants

M Knipper, P Van Dijk, H Schulze… - Journal of …, 2020 - Soc Neuroscience
Subjective tinnitus is the conscious perception of sound in the absence of any acoustic
source. The literature suggests various tinnitus mechanisms, most of which invoke changes …

Tinnitus and hyperacusis: central noise, gain and variance

FG Zeng - Current opinion in physiology, 2020 - Elsevier
Tinnitus is a phantom auditory sensation in the absence of external sounds, while
hyperacusis is an atypical sensitivity to external sounds that leads them to be perceived as …

Genetic architecture distinguishes tinnitus from hearing loss

RE Clifford, AX Maihofer, C Chatzinakos… - Nature …, 2024 - nature.com
Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical
specialties. Previous GWAS indicated high genetic correlations between tinnitus and …

[HTML][HTML] Neural generators of the frequency-following response elicited to stimuli of low and high frequency: a magnetoencephalographic (MEG) study

N Gorina-Careta, JLO Kurkela, J Hämäläinen… - Neuroimage, 2021 - Elsevier
The frequency-following response (FFR) to periodic complex sounds has gained recent
interest in auditory cognitive neuroscience as it captures with great fidelity the tracking …

Hyperacusis: Loudness intolerance, fear, annoyance and pain

R Salvi, GD Chen, S Manohar - Hearing research, 2022 - Elsevier
Hyperacusis is a debilitating loudness intolerance disorder that can evoke annoyance, fear
and aural facial pain. Although the auditory system seems to be the “central” player …

Cortical tonotopic map changes in humans are larger in hearing loss than in additional tinnitus

EA Koops, RJ Renken, CP Lanting… - Journal of …, 2020 - Soc Neuroscience
Neural plasticity due to hearing loss results in tonotopic map changes. Several studies have
suggested a relation between hearing loss-induced tonotopic reorganization and tinnitus …

Top-down and bottom-up regulated auditory phantom perception

S Vanneste, O Alsalman, D De Ridder - Journal of Neuroscience, 2019 - Soc Neuroscience
Auditory phantom percepts such as tinnitus are associated with auditory deafferentation. The
idea is that auditory deafferentation limits the amount of information the brain can acquire to …

Disturbed balance of inhibitory signaling links hearing loss and cognition

M Knipper, W Singer, K Schwabe… - Frontiers in Neural …, 2022 - frontiersin.org
Neuronal hyperexcitability in the central auditory pathway linked to reduced inhibitory
activity is associated with numerous forms of hearing loss, including noise damage, age …

Enhanced central neural gain compensates acoustic trauma-induced cochlear impairment, but unlikely correlates with tinnitus and hyperacusis

D Möhrle, B Hofmeier, M Amend, S Wolpert, K Ni… - Neuroscience, 2019 - Elsevier
For successful future therapeutic strategies for tinnitus and hyperacusis, a subcategorization
of both conditions on the basis of differentiated neural correlates would be of invaluable …

Detecting noise-induced cochlear synaptopathy by auditory brainstem response in tinnitus patients with normal hearing thresholds: A meta-analysis

F Chen, F Zhao, N Mahafza, W Lu - Frontiers in neuroscience, 2021 - frontiersin.org
Noise-induced cochlear synaptopathy (CS) is defined as a permanent loss of synapses in
the auditory nerve pathway following noise exposure. Several studies using auditory …