Targeting the translation machinery in cancer
Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …
tumour suppressors affect the translation machinery, making aberrant translation a …
Signaling pathways involved in the regulation of mRNA translation
PP Roux, I Topisirovic - Molecular and cellular biology, 2018 - Am Soc Microbiol
Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …
mTOR coordinates protein synthesis, mitochondrial activity and proliferation
Protein synthesis is one of the most energy consuming processes in the cell. The
mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that …
mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that …
New frontiers in translational control of the cancer genome
ML Truitt, D Ruggero - Nature Reviews Cancer, 2016 - nature.com
The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …
expression is rewired at the translation level during tumorigenesis to support the …
Growing knowledge of the mTOR signaling network
K Huang, DC Fingar - Seminars in cell & developmental biology, 2014 - Elsevier
The kinase mTOR (mechanistic target of rapamycin) integrates diverse environmental
signals and translates these cues into appropriate cellular responses. mTOR forms the …
signals and translates these cues into appropriate cellular responses. mTOR forms the …
[HTML][HTML] La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1)
The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of protein
synthesis. The best studied targets of mTORC1 in translation are the eukaryotic initiation …
synthesis. The best studied targets of mTORC1 in translation are the eukaryotic initiation …
[HTML][HTML] Protein synthesis and quality control in aging
AS Anisimova, AI Alexandrov, NE Makarova… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
Aging is characterized by the accumulation of damage and other deleterious changes,
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …
LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
S Hong, MA Freeberg, T Han, A Kamath, Y Yao… - Elife, 2017 - elifesciences.org
The RNA binding protein, LARP1, has been proposed to function downstream of mTORC1
to regulate the translation of 5'TOP mRNAs such as those encoding ribosome proteins (RP) …
to regulate the translation of 5'TOP mRNAs such as those encoding ribosome proteins (RP) …
Ribosomal protein S6 phosphorylation: four decades of research
O Meyuhas - International review of cell and molecular biology, 2015 - Elsevier
The phosphorylation of ribosomal protein S6 (rpS6) has been described for the first time
about four decades ago. Since then, numerous studies have shown that this modification …
about four decades ago. Since then, numerous studies have shown that this modification …
La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs
RM Lahr, BD Fonseca, GE Ciotti, HA Al-Ashtal, JJ Jia… - Elife, 2017 - elifesciences.org
The 5'terminal oligopyrimidine (5'TOP) motif is a cis-regulatory RNA element located
immediately downstream of the 7-methylguanosine [m7G] cap of TOP mRNAs, which …
immediately downstream of the 7-methylguanosine [m7G] cap of TOP mRNAs, which …