Interferon-beta (IFN-β) for Multiple Sclerosis (MS) is turning 30. The COVID-19 pandemic
rejuvenated the interest in interferon biology in health and disease, opening translational …

Anti-cytokine autoantibodies and, in particular, anti-type I interferons are increasingly
described in association with immunodeficient, autoimmune, and immune-dysregulated …

Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause
encephalitis in< 1% of infected individuals. We show that∼ 35% of patients hospitalized for …

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …

Autoantibodies neutralizing type I interferons (IFN-Is) can underlie infection severity. Here,
we trace the development of these autoantibodies at high-resolution using longitudinal …

Background Rabies remains a deadly zoonotic disease, primarily prevalent in Eastern
European countries, with a significant global burden in Asia and Africa. Post-exposure …

In humans, the interindividual variability of clinical outcome following exposure to a
microorganism is immense, ranging from silent infection to life-threatening disease. Age …

Genetic defects in the interferon (IFN) system or neutralizing autoantibodies against type I
IFNs contribute to severe COVID-19. Such autoantibodies were proposed to affect post …

Type I interferons, particularly IFNα-2b, play essential roles in eliciting adaptive and innate
immune responses, being implicated in the pathogenesis of various diseases, including …

Interferons (IFNs) are a critical component of innate immune defenses and limit viral disease
severity. To advance studies on IFNs and their neutralization by pathogenic autoantibodies …