Essence determines phenomenon: assaying the material properties of biological condensates
Intracellular spaces are partitioned into separate compartments to ensure that numerous
biochemical reactions and cellular functions take place in a spatiotemporally controlled …
biochemical reactions and cellular functions take place in a spatiotemporally controlled …
In diverse conditions, intrinsic chromatin condensates have liquid-like material properties
Nuclear DNA in eukaryotes is wrapped around histone proteins to form nucleosomes on a
chromatin fiber. Dynamic folding of the chromatin fiber into loops and variations in the …
chromatin fiber. Dynamic folding of the chromatin fiber into loops and variations in the …
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK
Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and
mutations. Their clinical symptoms are different. However, individuals with NDDs have …
mutations. Their clinical symptoms are different. However, individuals with NDDs have …
Recent advances and future perspectives in early‐maturing cotton research
H Zhao, Y Chen, J Liu, Z Wang, F Li, X Ge - New Phytologist, 2023 - Wiley Online Library
Cotton's fundamental requirements for long periods of growth and specific seasonal
temperatures limit the global arable areas that can be utilized to cultivate cotton. This …
temperatures limit the global arable areas that can be utilized to cultivate cotton. This …
Spatial organization of transcribed eukaryotic genes
S Leidescher, J Ribisel, S Ullrich, Y Feodorova… - Nature cell …, 2022 - nature.com
Despite the well-established role of nuclear organization in the regulation of gene
expression, little is known about the reverse: how transcription shapes the spatial …
expression, little is known about the reverse: how transcription shapes the spatial …
Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
EM Pujadas Liwag, X Wei, N Acosta, LM Carter, J Yang… - Genome biology, 2024 - Springer
Background B-type lamins are critical nuclear envelope proteins that interact with the three-
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
Suppression of liquid–liquid phase separation by 1, 6-hexanediol partially compromises the 3D genome organization in living cells
SV Ulianov, AK Velichko, MD Magnitov… - Nucleic acids …, 2021 - academic.oup.com
Liquid–liquid phase separation (LLPS) contributes to the spatial and functional segregation
of molecular processes within the cell nucleus. However, the role played by LLPS in …
of molecular processes within the cell nucleus. However, the role played by LLPS in …
The nuclear lamina
X Wong, AJ Melendez-Perez… - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin
regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear …
regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear …
[HTML][HTML] Multiscale modeling of genome organization with maximum entropy optimization
ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …
role in all DNA-templated processes, including gene transcription, gene regulation, and …
Physical nature of chromatin in the nucleus
K Maeshima, S Iida, S Tamura - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
Genomic information is encoded on long strands of DNA, which are folded into chromatin
and stored in a tiny nucleus. Nuclear chromatin is a negatively charged polymer composed …
and stored in a tiny nucleus. Nuclear chromatin is a negatively charged polymer composed …