Despite advances in the identification of chromatin regulators and genome interactions, the
principles of higher‐order chromatin structure have remained elusive. Here, we applied …

Chromatin in eukaryotic cells is a negatively charged long polymer consisting of DNA,
histones, and various associated proteins. With its highly charged and heterogeneous …

Chromatin plays an essential role in the nuclear mechanical response and determining
nuclear shape, which maintain nuclear compartmentalization and function. However, major …

Living organisms typically store their genomic DNA in a condensed form. Mechanistically,
DNA condensation can be driven by macromolecular crowding, multivalent cations, or …

In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical
properties of the nucleus and its ability to sense external mechanical cues are tightly linked …

Transcription is a core step in gene expression. Regulation of transcription is achieved at the
level of transcription machinery, local chromatin environment as well as higher-order …

The majority of our genome is composed of repeated DNA sequences that assemble into
heterochromatin, a highly compacted structure that constrains their mutational potential …

We show evidence of the association of RNA polymerase II (RNAP) with chromatin in a core-
shell organization, reminiscent of microphase separation where the cores comprise dense …

While major changes in cellular morphology during apoptosis have been well described, the
subcellular changes in nuclear architecture involved in this process remain poorly …

Probing the architecture, mechanism, and dynamics of genome folding is fundamental to our
understanding of genome function in homeostasis and disease. Most chromosome …