Although textbook pictures depict the cell nucleus as a simple ovoid object, it is now clear
that it adopts a large variety of shapes in tissues. When cells deform, because of cell …

DNA is a highly charged polyelectrolyte and is prone to associative phase separation driven
by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids …

Imbalance in the finely orchestrated system of chromatin-modifying enzymes is a hallmark of
many pathologies such as cancers, since causing the affection of the epigenome and …

Our understanding of the spatiotemporal regulation of eukaryotic gene expression has
recently been greatly stimulated by the findings that many of the regulators of chromatin …

How chromatin enzymes work in condensed chromatin and how they maintain diffusional
mobility inside remains unexplored. Here we investigated these challenges using the …

Nucleic acid condensates are essential for various biological processes and have numerous
applications in nucleic acid nanotechnology, gene therapy, and mRNA vaccines. However …

Nucleosome chains fold and self-associate to form higher-order structures whose internal
organization is unknown. Here, cryoelectron tomography (cryo-ET) of native human …

Little is understood about how the two major types of heterochromatin domains (HP1 and
Polycomb) are kept separate. In the yeast Cryptococcus neoformans, the Polycomb-like …

The dynamic regulation of the physical states of chromatin in the cell nucleus is crucial for
maintaining cellular homeostasis. Chromatin can exist in solid-or liquid-like forms …

Chromatin compaction differences may have a strong impact on accessibility of individual
macromolecules and macromolecular assemblies to their DNA target sites. Estimates based …