The genetic material of eukaryotes is segregated into transcriptionally active euchromatin
and silent heterochromatin compartments. The spatial arrangement of chromatin …

The nucleus is a mechanically stable compartment of the cell that contains the genome and
performs many essential functions. Nuclear mechanical components chromatin and lamins …

After 60 years of chromatin investigation, our understanding of chromatin organization has
evolved from static chromatin fibers to dynamic nuclear compartmentalization. Chromatin is …

Chromatin is a unique structure of DNA and histone proteins in the cell nucleus and the site
of dynamic regulation of gene expression. Soluble factors are known to affect the chromatin …

Biomolecular condensates, sometimes also known as membraneless organelles (MLOs),
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …

DNA molecules with a total length of two meters contain the genetic information in every cell
in our body. To control access to the genes, to organize its spatial structure in the nucleus …

Eukaryotic genome DNA is wrapped around core histones and forms a nucleosome
structure. Together with associated proteins and RNAs, these nucleosomes are organized …

Cells remodel their cytoplasm with force-generating cytoskeletal motors. Their activity
generates random forces that stir the cytoplasm, agitating and displacing membrane-bound …

Molecular mechanisms that dictate chromatin organization in vivo are under active
investigation, and the extent to which intrinsic interactions contribute to this process remains …

The nucleosome comprises two histone dimers of H2A-H2B and one histone tetramer of (H3-
H4) 2, wrapped around by∼ 145bp of DNA. Detailed core structures of nucleosomes have …